Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 20/20 | 0.55 |
| ▸ | TRPV4 | Q9HBA0 | 7/20 | 0.46 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13537689 | 0.86 | TRPA1 (0.53) | TRPA1TRPV4 | |
| SCHEMBL1800907 | 0.72 | TRPA1 (0.75) | TRPA1TRPV4TRPV3 | |
| SCHEMBL1799998 | 0.72 | TRPA1 (0.89) | TRPA1TRPV4TRPV3 | |
| SCHEMBL1802273 | 0.71 | TRPA1 (1.00) | TRPA1TRPV4TRPV3 | |
| SCHEMBL20249922 | 0.69 | NPC1 (0.46) | — | |
| SCHEMBL1800518 | 0.68 | TRPA1 (0.83) | TRPA1TRPV4TRPV3 | |
| SCHEMBL1802478 | 0.67 | TRPA1 (1.00) | TRPA1TRPV4TRPV3 | |
| SCHEMBL1803394 | 0.66 | TRPA1 (0.86) | TRPA1TRPV4TRPV3 | |
| SCHEMBL1800443 | 0.66 | TRPA1 (0.61) | TRPA1TRPV4TRPV3 | |
| SCHEMBL1799993 | 0.66 | TRPA1 (1.00) | TRPA1TRPV4TRPV3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010004390-A1 | QUINAZOLINE DIONE DERIVATIVES AS TRPA1 MODULATORS | GLENMARK PHARMACEUTICALS, S.A. (CH) | 2010-01-14 | — | — | WO | disclosed |