Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 7/20 | 0.74 |
| ▸ | PIM2 | Q9P1W9 | 7/20 | 0.74 |
| ▸ | PIM3 | Q86V86 | 6/20 | 0.74 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | BTK | Q06187 | 1/20 | 0.37 |
| ▸ | CKS1B | P61024 | 1/20 | 0.36 |
| ▸ | SKP1 | P63208 | 1/20 | 0.36 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.36 |
| ▸ | CTSK | P43235 | 2/20 | 0.36 |
| ▸ | F10 | P00742 | 1/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16468722 | 0.93 | PIM1 (0.77) | PIM1PIM2PIM3POLBGPR119 | |
| SCHEMBL12282933 | 0.93 | PIM1 (0.77) | PIM1PIM2PIM3POLBGPR119 | |
| SCHEMBL16468720 | 0.93 | PIM1 (0.77) | PIM1PIM2PIM3POLBGPR119 | |
| SCHEMBL2426642 | 0.89 | PIM2 (0.69) | PIM1PIM2PIM3POLBBTK | |
| SCHEMBL2426638 | 0.89 | PIM2 (0.69) | PIM1PIM2PIM3POLBBTK | |
| SCHEMBL2426644 | 0.89 | PIM2 (0.69) | PIM1PIM2PIM3POLBBTK | |
| SCHEMBL2426637 | 0.89 | PIM2 (0.69) | PIM1PIM2PIM3POLBBTK | |
| SCHEMBL2420001 | 0.86 | PIM2 (0.68) | PIM1PIM2PIM3BTKF10 | |
| SCHEMBL2426038 | 0.86 | PIM2 (0.68) | PIM1PIM2PIM3BTKF10 | |
| SCHEMBL2429998 | 0.86 | PIM1 (0.75) | PIM1PIM2PIM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010001169-A2 | CHEMICAL COMPOUNDS 251 | ASTRAZENECA AB (SE) | 2010-01-07 | — | — | WO | disclosed |