Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AB1 | P08238 | 19/20 | 0.55 |
| ▸ | HSP90AA1 | P07900 | 19/20 | 0.54 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.38 |
| ▸ | TRAP1 | Q12931 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13539741 | 0.89 | HSP90AB1 (0.47) | HSP90AB1HSP90AA1 | |
| SCHEMBL13616277 | 0.83 | HSP90AB1 (0.70) | HSP90AB1HSP90AA1 | |
| SCHEMBL13539735 | 0.81 | HSP90AA1 (0.48) | HSP90AB1HSP90AA1HSP90B1TRAP1 | |
| SCHEMBL13539714 | 0.81 | HSP90AA1 (0.71) | HSP90AB1HSP90AA1HSP90B1TRAP1 | |
| SCHEMBL13539719 | 0.80 | HSP90AA1 (0.46) | HSP90AB1HSP90AA1HSP90B1TRAP1 | |
| SCHEMBL13539631 | 0.79 | HSP90AA1 (0.47) | HSP90AB1HSP90AA1HSP90B1TRAP1 | |
| SCHEMBL14567691 | 0.78 | HSP90AA1 (0.46) | HSP90AB1HSP90AA1HSP90B1TRAP1 | |
| SCHEMBL13539447 | 0.78 | HSP90AA1 (0.54) | HSP90AB1HSP90AA1HSP90B1TRAP1 | |
| SCHEMBL13539630 | 0.78 | HSP90AA1 (0.51) | HSP90AB1HSP90AA1HSP90B1TRAP1 | |
| SCHEMBL14567690 | 0.77 | HSP90AA1 (0.41) | HSP90AB1HSP90AA1HSP90B1TRAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2145888-A1 | Deazapurine derivatives as HSP90-Inhibitors | Conforma Therapeutics Corporation (US) | 2010-01-20 | — | — | EP | disclosed |