Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 16/20 | 0.50 |
| ▸ | TRAP1 | Q12931 | 9/20 | 0.50 |
| ▸ | HSP90B1 | P14625 | 7/20 | 0.50 |
| ▸ | HSP90AB1 | P08238 | 11/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3391833 | 0.87 | HSP90AA1 (0.57) | HSP90AA1TRAP1HSP90B1HSP90AB1 | |
| SCHEMBL13539742 | 0.85 | HSP90AA1 (0.59) | HSP90AA1TRAP1HSP90B1HSP90AB1 | |
| SCHEMBL1052242 | 0.83 | HSP90AA1 (0.62) | HSP90AA1TRAP1HSP90B1HSP90AB1 | |
| SCHEMBL5566304 | 0.82 | HSP90AA1 (0.53) | HSP90AA1TRAP1HSP90B1HSP90AB1 | |
| SCHEMBL12615628 | 0.81 | HSP90AA1 (0.59) | HSP90AA1TRAP1HSP90B1HSP90AB1 | |
| SCHEMBL1060933 | 0.77 | HSP90AA1 (0.56) | HSP90AA1TRAP1HSP90B1HSP90AB1 | |
| SCHEMBL12651963 | 0.74 | HSP90AA1 (0.59) | HSP90AA1TRAP1HSP90B1HSP90AB1 | |
| SCHEMBL1060436 | 0.74 | TRAP1 (0.66) | HSP90AA1TRAP1HSP90B1 | |
| SCHEMBL1079346 | 0.70 | HSP90AA1 (0.60) | HSP90AA1TRAP1HSP90B1HSP90AB1 | |
| SCHEMBL1078262 | 0.70 | HSP90AA1 (0.57) | HSP90AA1TRAP1HSP90B1HSP90AB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2145888-A1 | Deazapurine derivatives as HSP90-Inhibitors | Conforma Therapeutics Corporation (US) | 2010-01-20 | — | — | EP | disclosed |