Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 5/20 | 0.43 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.39 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.35 |
| ▸ | MTOR | P42345 | 2/20 | 0.35 |
| ▸ | RPTOR | Q8N122 | 2/20 | 0.35 |
| ▸ | MLST8 | Q9BVC4 | 2/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.34 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.34 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.34 |
| ▸ | DPP4 | P27487 | 1/20 | 0.33 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.33 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.33 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.33 |
| ▸ | LDHA | P00338 | 1/20 | 0.33 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.32 |
| ▸ | GPR6 | P46095 | 1/20 | 0.32 |
| ▸ | PGR | P06401 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8221486 | 0.85 | ADAM17 (0.43) | ADAM17CHRM4USP30MTORRPTOR | |
| SCHEMBL12240084 | 0.84 | ADAM17 (0.44) | ADAM17CHRM4USP30MTORRPTOR | |
| SCHEMBL8221453 | 0.82 | ADAM17 (0.53) | ADAM17CHRM4USP30MTORRPTOR | |
| SCHEMBL8221438 | 0.82 | ADAM17 (0.53) | ADAM17CHRM4USP30MTORRPTOR | |
| SCHEMBL8273348 | 0.82 | ADAM17 (0.53) | ADAM17CHRM4USP30MTORRPTOR | |
| SCHEMBL8213698 | 0.81 | ADAM17 (0.53) | ADAM17CHRM4USP30MTORRPTOR | |
| SCHEMBL8213677 | 0.81 | ADAM17 (0.48) | ADAM17CHRM4USP30SCN9ASCN5A | |
| SCHEMBL8223463 | 0.81 | ADAM17 (0.49) | ADAM17CHRM4USP30MTORRPTOR | |
| SCHEMBL8222728 | 0.81 | ADAM17 (0.49) | ADAM17CHRM4USP30MTORRPTOR | |
| SCHEMBL8223432 | 0.80 | ADAM17 (0.49) | ADAM17CHRM4SCN9ASCN5AFFAR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7652020-B2 | novel hydantoin derivatives to inhibit matrix metalloproteinases (MMPs), a disintegrin and metalloproteases (ADAMs) and/or tumor necrosis factor alpha converting enzyme (TACE) and in so doing prevent the release of tumor necrosis factor alpha (TNF- alpha ); autoimmune diseases; side effect reduction | SCHERING CORPORATION (US) | 2010-01-26 | — | — | US | disclosed |