Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | PIK3C3 | Q8NEB9 | 13/20 | 0.46 |
| ▸ | JAK2 | O60674 | 2/20 | 0.45 |
| ▸ | JAK1 | P23458 | 2/20 | 0.45 |
| ▸ | TYK2 | P29597 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22809544 | 0.87 | L3MBTL1 (0.49) | L3MBTL1PIK3C3JAK2JAK1TYK2 | |
| SCHEMBL25229978 | 0.86 | L3MBTL1 (0.47) | L3MBTL1PIK3C3JAK2JAK1TYK2 | |
| SCHEMBL12647584 | 0.83 | KDM4D (0.42) | JAK2JAK1TYK2RAB9ANPC1 | |
| SCHEMBL10264295 | 0.83 | L3MBTL1 (0.55) | L3MBTL1PIK3C3JAK2JAK1TYK2 | |
| SCHEMBL19736343 | 0.83 | BRD4 (0.48) | L3MBTL1PIK3C3JAK2JAK1TYK2 | |
| SCHEMBL256750 | 0.81 | KDM4D (0.54) | L3MBTL1PIK3C3JAK2JAK1TYK2 | |
| SCHEMBL2998251 | 0.81 | KDM4E (0.49) | L3MBTL1PIK3C3JAK2JAK1TYK2 | |
| SCHEMBL6935872 | 0.80 | JMJD6 (0.51) | PIK3C3RAB9ANPC1PKMSMN1; SMN2 | |
| SCHEMBL25188111 | 0.80 | L3MBTL1 (0.52) | L3MBTL1PIK3C3JAK2JAK1TYK2 | |
| SCHEMBL8092962 | 0.80 | L3MBTL1 (0.52) | L3MBTL1PIK3C3JAK2JAK1TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7645771-B2 | CCR5 antagonists as therapeutic agents | SMITHKLINE BEECHAM CORP. (US) | 2010-01-12 | — | — | US | disclosed |