Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 9/20 | 0.51 |
| ▸ | ROCK1 | Q13464 | 6/20 | 0.47 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.43 |
| ▸ | EGFR | P00533 | 4/20 | 0.41 |
| ▸ | FLT1 | P17948 | 3/20 | 0.41 |
| ▸ | RET | P07949 | 2/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
| ▸ | PAK4 | O96013 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.41 |
| ▸ | LCK | P06239 | 1/20 | 0.41 |
| ▸ | FYN | P06241 | 1/20 | 0.41 |
| ▸ | CSF1R | P07333 | 1/20 | 0.41 |
| ▸ | IGF1R | P08069 | 1/20 | 0.41 |
| ▸ | MET | P08581 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13547636 | 0.89 | ROCK2 (0.55) | ROCK2ROCK1MKNK1EGFRFLT1 | |
| SCHEMBL13220497 | 0.89 | ROCK2 (0.51) | ROCK2ROCK1MKNK1EGFRFLT1 | |
| SCHEMBL13220401 | 0.85 | ROCK2 (0.52) | ROCK2ROCK1MKNK1EGFRFLT1 | |
| SCHEMBL13220503 | 0.85 | ROCK2 (0.51) | ROCK2ROCK1MKNK1EGFRFLT1 | |
| SCHEMBL13547588 | 0.84 | HSF1 (0.48) | ROCK2ROCK1MKNK1EGFRFLT1 | |
| SCHEMBL13220518 | 0.84 | ROCK2 (0.48) | ROCK2ROCK1MKNK1EGFRFLT1 | |
| SCHEMBL13220333 | 0.83 | ROCK2 (0.51) | ROCK2ROCK1MKNK1EGFRFLT1 | |
| SCHEMBL13241612 | 0.81 | ROCK2 (0.49) | ROCK2ROCK1MKNK1EGFRFLT1 | |
| SCHEMBL13220452 | 0.81 | ROCK2 (0.55) | ROCK2ROCK1MKNK1EGFRFLT1 | |
| SCHEMBL13220422 | 0.81 | ROCK2 (0.55) | ROCK2ROCK1MKNK1EGFRFLT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7648986-B2 | Substituted thieno[3,2-D]pyrimidines as Rho kinase inhibitors | BAYER HEALTHCARE LLC (US) | 2010-01-19 | — | — | US | disclosed |