Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 20/20 | 0.75 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.75 |
| ▸ | CYP2C9 | P11712 | 11/20 | 0.69 |
| ▸ | CYP3A4 | P08684 | 10/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL118651 | 0.91 | HSD11B1 (0.76) | HSD11B1CYP2C19CYP2C9CYP3A4 | |
| SCHEMBL118652 | 0.91 | HSD11B1 (0.76) | HSD11B1CYP2C19CYP2C9CYP3A4 | |
| SCHEMBL118653 | 0.91 | HSD11B1 (0.76) | HSD11B1CYP2C19CYP2C9CYP3A4 | |
| SCHEMBL120593 | 0.87 | HSD11B1 (0.68) | HSD11B1CYP2C19CYP2C9CYP3A4 | |
| SCHEMBL120594 | 0.87 | HSD11B1 (0.68) | HSD11B1CYP2C19CYP2C9CYP3A4 | |
| SCHEMBL957557 | 0.86 | HSD11B1 (0.83) | HSD11B1CYP2C19CYP2C9CYP3A4 | |
| SCHEMBL957558 | 0.86 | HSD11B1 (0.83) | HSD11B1CYP2C19CYP2C9CYP3A4 | |
| SCHEMBL15959057 | 0.86 | HSD11B1 (0.83) | HSD11B1CYP2C19CYP2C9CYP3A4 | |
| SCHEMBL117676 | 0.86 | HSD11B1 (1.00) | HSD11B1CYP2C19CYP2C9CYP3A4 | |
| SCHEMBL117677 | 0.86 | HSD11B1 (1.00) | HSD11B1CYP2C19CYP2C9CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2687525-A1 | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 | Boehringer Ingelheim International GmbH (DE) | 2014-01-22 | — | — | EP | disclosed |
| WO-2010011314-A1 | CYCLIC INHIBITORS OF 11 BETA-HYDROXYSTEROID DEHYDROGENASE 1 | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-01-28 | — | — | WO | disclosed |