Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | DHFR | P00374 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | PANK3 | Q9H999 | 1/20 | 0.36 |
| ▸ | GALR1 | P47211 | 3/20 | 0.36 |
| ▸ | GALR2 | O43603 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | DRD2 | P14416 | 2/20 | 0.35 |
| ▸ | DRD3 | P35462 | 2/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.35 |
| ▸ | GFER | P55789 | 1/20 | 0.35 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3244309 | 0.87 | MEN1 (0.49) | MEN1KMT2AKDM4EMAPTHSD17B10 | |
| SCHEMBL3245969 | 0.84 | MEN1 (0.49) | MEN1KMT2ADHFRKDM4EMAPT | |
| SCHEMBL3247897 | 0.83 | MEN1 (0.49) | MEN1KMT2ADHFRKDM4EMAPT | |
| SCHEMBL3242750 | 0.83 | MEN1 (0.49) | MEN1KMT2ADHFRKDM4EMAPT | |
| SCHEMBL3244007 | 0.83 | MEN1 (0.49) | MEN1KMT2ADHFRKDM4EMAPT | |
| SCHEMBL3245980 | 0.83 | MEN1 (0.45) | MEN1KMT2ADHFRKDM4EMAPT | |
| SCHEMBL8254119 | 0.82 | KDM4E (0.48) | KDM4EMAPTHSD17B10LMNATP53 | |
| SCHEMBL3240653 | 0.81 | ALDH1A1 (0.48) | MEN1KMT2AKDM4EMAPTHSD17B10 | |
| SCHEMBL3262025 | 0.80 | KDM4E (0.43) | KDM4EMAPTHSD17B10LMNATP53 | |
| SCHEMBL3247614 | 0.78 | MAPT (0.45) | KDM4EMAPTHSD17B10LMNATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2140862-A2 | Use of GAL 3 receptor antagonists for the treatment of depression and /or anxiety and compounds useful in such methods | H.Lundbeck A/S (DK) | 2010-01-06 | — | — | EP | disclosed |