Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 5/20 | 0.65 |
| ▸ | MAPT | P10636 | 4/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.65 |
| ▸ | RECQL | P46063 | 4/20 | 0.65 |
| ▸ | APEX1 | P27695 | 3/20 | 0.65 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.65 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.65 |
| ▸ | SLCO2B1 | O94956 | 2/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.65 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.65 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.65 |
| ▸ | MEN1 | O00255 | 2/20 | 0.65 |
| ▸ | BLM | P54132 | 2/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.65 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.65 |
| ▸ | RGS12 | O14924 | 1/20 | 0.65 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.65 |
| ▸ | USP2 | O75604 | 1/20 | 0.65 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.65 |
| ▸ | APP | P05067 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7914456 | 0.88 | POLH (0.79) | POLBMAPTKDM4ERECQLAPEX1 | |
| SCHEMBL10041306 | 0.83 | POLB (0.77) | POLBMAPTKDM4ERECQLAPEX1 | |
| Myricetin SCHEMBL29357150 | 0.80 | MEN1 (1.00) | POLBMAPTKDM4ERECQLAPEX1 | |
| Myricetin SCHEMBL19302 | 0.80 | MEN1 (1.00) | POLBMAPTKDM4ERECQLAPEX1 | |
| Myricetin SCHEMBL3503992 | 0.80 | MEN1 (1.00) | POLBMAPTKDM4ERECQLAPEX1 | |
| SCHEMBL6685824 | 0.79 | EPHX2 (0.85) | POLBMAPTKDM4ERECQLAPEX1 | |
| SCHEMBL13552041 | 0.76 | MEN1 (0.76) | POLBMAPTKDM4ERECQLAPEX1 | |
| SCHEMBL3777085 | 0.76 | EPHX2 (0.80) | POLBMAPTKDM4ERECQLAPEX1 | |
| SCHEMBL10728956 | 0.76 | POLH (1.00) | POLBMAPTKDM4ERECQLAPEX1 | |
| SCHEMBL7202826 | 0.76 | POLH (1.00) | POLBMAPTKDM4ERECQLAPEX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120270821-A1 | CDK5 Inhibitors and Therapeutic Uses Thereof | THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY (CN) | 2012-10-25 | — | — | US | disclosed |
| US-20090124688-A1 | Prostaglandin reductase inhibitors | ABGENOMICS CORPORATION (TW) | 2009-05-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090124688-A1 | Prostaglandin reductase inhibitors | PTGIR, PTGDR, PTGDR2 | POLB 1803/4885MAPT 4718/4885KDM4E 2123/4885 |
| US-20120270821-A1 | CDK5 Inhibitors and Therapeutic Uses Thereof | CDK5, CDK3, CDKL1 | POLB 1107/4885MAPT 348/4885KDM4E 1676/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.