POLH — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL3032358	0.71	10/20
SCHEMBL3718557	0.69	10/20
SCHEMBL824468	1.00	9/20
Luteolin (SCHEMBL1229732)	0.75	9/20
SCHEMBL119670	0.73	9/20
Luteolin (SCHEMBL20426)	1.00	8/20
3-O-Methylquercetin (SCHEMBL380558)	1.00	8/20
Luteolin (SCHEMBL1659262)	0.97	8/20
SCHEMBL3029675	0.76	8/20
SCHEMBL119377	0.75	8/20
SCHEMBL3757805	0.74	8/20
SCHEMBL120009	0.72	8/20
SCHEMBL120010	0.72	8/20
SCHEMBL3403244	0.72	8/20
SCHEMBL925099	0.71	8/20
SCHEMBL4036334	0.66	8/20
SCHEMBL4036338	0.66	8/20
SCHEMBL455660	0.63	8/20
SCHEMBL455661	0.63	8/20
SCHEMBL469569	0.63	8/20

Clinical trials — most relevant to POLH by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Refining Fertility-sparing Treatment in Endometrial Carcinoma Based on Molecular Classification	PHASE2/PHASE3	RECRUITING
Intracameral Antibiotic Safety Study	PHASE3	SUSPENDED
Avelumab for MSI-H or POLE Mutated Metastatic Colorectal Cancer	PHASE2	UNKNOWN
Durvalumab for MSI-H or POLE Mutated Metastatic Colorectal Cancer	PHASE2	COMPLETED
Study Evaluating the Efficacy of a Double Immunotherapy Combined With Olaparib in Patients With Solid Cancers and Carriers of Homologous Recombination Repair Genes After Olaparib Treatment	PHASE2	ACTIVE_NOT_RECRUITING
Pembrolizumab in Treating Participants With Metastatic, Recurrent or Locally Advanced Cancer and Genomic Instability	PHASE2	ACTIVE_NOT_RECRUITING
Selective Treatment According to Molecular Subtype of Prostate Cancer	PHASE2	UNKNOWN
Gemcitabine Hydrochloride and Cisplatin With or Without Veliparib or Veliparib Alone in Treating Patients With Locally Advanced or Metastatic Pancreatic Cancer	PHASE2	ACTIVE_NOT_RECRUITING
Olaparib in People With Malignant Mesothelioma	PHASE2	COMPLETED
Bipolar Androgen Therapy + Carboplatin in mCRPC	PHASE2	RECRUITING
Phase II ABT-888 With Cyclophosphamide	PHASE2	COMPLETED
Trial of Rucaparib in Patients With Metastatic Hormone-Sensitive Prostate Cancer Harboring Germline DNA Repair Gene Mutations	PHASE2	COMPLETED
Chlorambucil in Metastatic PDAC Patients Bearing a Germ Line DNA Defects Repair Mutations (SALE Trial)	PHASE2	UNKNOWN
A Study of ART4215 for the Treatment of Advanced or Metastatic Solid Tumors	PHASE1	COMPLETED
Safety Study of ABT-888 Plus Topotecan Hydrochloride to Treat Patients With Solid Tumors and Lymphomas	PHASE1	COMPLETED
A Phase I Study of ABT-888, an Oral Inhibitor of Poly(ADP-ribose) Polymerase and Temozolomide in Children With Recurrent/Refractory CNS Tumors	PHASE1	COMPLETED
Study of Orally Administered MOMA-313 in Participants With Advanced or Metastatic Solid Tumors	PHASE1	ACTIVE_NOT_RECRUITING
AZD2281 and Cisplatin Plus Gemcitabine to Treat Solid Tumor Cancers	PHASE1	COMPLETED
LBH589 Oral in Combination With Carboplatin and Paclitaxel in Advanced Solid Tumors	PHASE1	UNKNOWN
Cohort of Tumors With POLE/D1 Mutation	nan	RECRUITING
REal Word aPpLicAtion of Molecular Based Endometrial Cancer Classification	nan	RECRUITING
Prevalence of Germline Alterations in Actionable Genes in Endometrial Cancer	nan	NOT_YET_RECRUITING
DNA Repair Genes and Outcomes in Patients With Stage III NSCLC	nan	UNKNOWN
Chronic Cough and CANVAS (Cerebellar Ataxia With Neuropathy and Bilateral Vestibular Areflexia Syndrome)	nan	COMPLETED
A Proof of Concept Study for the DNA Repair Driven by the Mesenchymal Stem Cells in Critical COVID-19 Patients	nan	COMPLETED
Effect of Adenovirus E1A Oncogene on DNA Replication Dynamics	nan	UNKNOWN
DNA Damage & Repair Proteins In Patients With Atherosclerotic Coronary Artery Disease	nan	COMPLETED
Plant Extracted Natural Compounds Impact on Stage IV Breast Cancer Survival Time and Remission.	nan	UNKNOWN
Utilizing a Multi-gene Testing Approach to Identify Hereditary Pancreatic Cancer	nan	COMPLETED
The Genetic and the Functional Study of DNA Repair System and the Susceptibility to Rheumatoid Arthritis	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a POLH binder may also engage these)

Protein	Name	Similarity
Q9JJN0	—	1.000	Q9JJN0 →
Q9QUG2	—	0.987	Q9QUG2 →
Q6R3M4	—	0.981	Q6R3M4 →
POLK	DNA polymerase kappa	0.980	landscape →
A3EWL3	—	0.978	A3EWL3 →
Q8H2D5	—	0.977	Q8H2D5 →
Q7SXA9	—	0.976	Q7SXA9 →
Q640B4	—	0.976	Q640B4 →
Q2VPA6	—	0.975	Q2VPA6 →
Q920Q2	—	0.975	Q920Q2 →
Q6DDT4	—	0.975	Q6DDT4 →
Q8BMI4	—	0.975	Q8BMI4 →
Q5U4Z3	—	0.975	Q5U4Z3 →
O89033	—	0.975	O89033 →
Q9VNX1	—	0.974	Q9VNX1 →
Q8GT06	—	0.974	Q8GT06 →
Q99741	—	0.974	Q99741 →
Q9D2E2	—	0.974	Q9D2E2 →
Q9UJY4	—	0.974	Q9UJY4 →
P54276	—	0.973	P54276 →
D3Z8X7	—	0.973	D3Z8X7 →
Q8BGE5	—	0.973	Q8BGE5 →
Q6NZP1	—	0.972	Q6NZP1 →
P97874	—	0.972	P97874 →
A8HAL1	—	0.972	A8HAL1 →
Q96AY2	—	0.972	Q96AY2 →
Q8VID5	—	0.972	Q8VID5 →
P14629	—	0.972	P14629 →
Q9FNY4	—	0.972	Q9FNY4 →
Q5I2W8	—	0.972	Q5I2W8 →