Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 20/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1913401 | 1.00 | PDPK1 (0.71) | PDPK1 | |
| SCHEMBL13554583 | 1.00 | PDPK1 (0.71) | PDPK1 | |
| SCHEMBL1913505 | 0.90 | PDPK1 (0.66) | PDPK1 | |
| SCHEMBL1913471 | 0.90 | PDPK1 (0.66) | PDPK1 | |
| SCHEMBL1913597 | 0.88 | PDPK1 (0.64) | PDPK1 | |
| SCHEMBL1913630 | 0.88 | PDPK1 (0.64) | PDPK1 | |
| SCHEMBL1913534 | 0.88 | PDPK1 (0.64) | PDPK1 | |
| SCHEMBL12530656 | 0.88 | PDPK1 (0.65) | PDPK1 | |
| SCHEMBL12530668 | 0.88 | PDPK1 (0.67) | PDPK1 | |
| SCHEMBL1916381 | 0.87 | PDPK1 (0.53) | PDPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2516431-B1 | PYRROLOPYRIDINYL-PYRIMIDIN-2-YLAMINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2015-04-15 | — | — | EP | disclosed |
| US-8575163-B2 | Pyrrolopyridinylpyrimidin-2-ylamine derivatives | MERCK PATENT GMBH (DE) | 2013-11-05 | — | — | US | disclosed |
| US-8575163-B2 | Pyrrolopyridinylpyrimidin-2-ylamine derivatives | MERCK PATENT GMBH (DE) | 2013-11-05 | — | — | US | disclosed |
| US-20120270871-A1 | PYRROLOPYRIDINYLPYRIMIDIN-2-YLAMINE DERIVATIVES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2012-10-25 | — | — | US | disclosed |
| US-20120270871-A1 | PYRROLOPYRIDINYLPYRIMIDIN-2-YLAMINE DERIVATIVES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2012-10-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120270871-A1 | PYRROLOPYRIDINYLPYRIMIDIN-2-YLAMINE DERIVATIVES | MKI67, CCNI, CCNT1 | PDPK1 425/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.