Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | CDK2 | P24941 | 1/20 | 0.48 |
| ▸ | FLT3 | P36888 | 1/20 | 0.48 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 5/20 | 0.46 |
| ▸ | NPC1 | O15118 | 5/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | HPGDS | O60760 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13554746 | 0.91 | NPC1 (0.47) | ALDH1A1SMN1; SMN2CDK2FLT3CCNA1 | |
| SCHEMBL13552960 | 0.90 | ALDH1A1 (0.52) | ALDH1A1SMN1; SMN2CDK2FLT3CCNA1 | |
| SCHEMBL13554744 | 0.86 | CDK2 (0.41) | ALDH1A1SMN1; SMN2CDK2FLT3CCNA1 | |
| SCHEMBL15502918 | 0.81 | CDK2 (0.49) | ALDH1A1SMN1; SMN2CDK2FLT3CCNA1 | |
| SCHEMBL13552961 | 0.81 | KMT2A (0.51) | ALDH1A1SMN1; SMN2NPC1LMNAKMT2A | |
| SCHEMBL14707447 | 0.80 | SMN1; SMN2 (0.41) | ALDH1A1SMN1; SMN2CDK2FLT3CCNA1 | |
| SCHEMBL14707448 | 0.80 | ABL1 (0.42) | ALDH1A1SMN1; SMN2CDK2FLT3CCNA1 | |
| SCHEMBL13554684 | 0.79 | MEN1 (0.46) | ALDH1A1SMN1; SMN2RAB9ANPC1LMNA | |
| SCHEMBL13552819 | 0.78 | NPC1 (0.58) | ALDH1A1SMN1; SMN2CDK2FLT3CCNA1 | |
| SCHEMBL13554833 | 0.77 | QPCT (0.47) | ALDH1A1SMN1; SMN2RAB9ANPC1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120270858-A1 | Isoquinoline, quinoline, and quinazoline derivatives as inhibitors of hedgehog signaling | CALIFORNIA CAPITAL EQUITY, LLC (US) | 2012-10-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120270858-A1 | Isoquinoline, quinoline, and quinazoline derivatives as inhibitors of hedgehog signaling | SHH, GLI1, SMO | ALDH1A1 2485/4885SMN1; SMN2 4323/4885CDK2 259/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.