Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR4 | P22455 | 6/20 | 0.56 |
| ▸ | EIF2AK4 | Q9P2K8 | 1/20 | 0.56 |
| ▸ | JAK2 | O60674 | 3/20 | 0.54 |
| ▸ | JAK3 | P52333 | 3/20 | 0.54 |
| ▸ | EGFR | P00533 | 1/20 | 0.51 |
| ▸ | KDR | P35968 | 1/20 | 0.51 |
| ▸ | BRD4 | O60885 | 1/20 | 0.50 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.50 |
| ▸ | FLT3 | P36888 | 1/20 | 0.49 |
| ▸ | SYK | P43405 | 2/20 | 0.49 |
| ▸ | JAK1 | P23458 | 1/20 | 0.49 |
| ▸ | AURKA | O14965 | 2/20 | 0.48 |
| ▸ | CDK4 | P11802 | 1/20 | 0.48 |
| ▸ | TTK | P33981 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.47 |
| ▸ | CDK2 | P24941 | 1/20 | 0.47 |
| ▸ | CDK9 | P50750 | 1/20 | 0.47 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1353747 | 0.91 | AURKA (0.58) | FGFR4JAK2JAK3EGFRKDR | |
| SCHEMBL1355729 | 0.89 | FGFR4 (0.50) | FGFR4EIF2AK4JAK2JAK3EGFR | |
| SCHEMBL1353760 | 0.87 | EGFR (0.65) | FGFR4EIF2AK4EGFRKDRBRD4 | |
| SCHEMBL1355752 | 0.86 | EIF2AK4 (0.62) | FGFR4EIF2AK4EGFRKDRTBK1 | |
| SCHEMBL1355170 | 0.85 | EIF2AK4 (0.61) | FGFR4EIF2AK4EGFRKDRTBK1 | |
| SCHEMBL1353701 | 0.84 | EIF2AK4 (0.60) | FGFR4EIF2AK4EGFRKDRBRD4 | |
| SCHEMBL1356098 | 0.84 | EIF2AK4 (0.62) | FGFR4EIF2AK4JAK2JAK3EGFR | |
| SCHEMBL1355988 | 0.84 | FLT3 (0.64) | FGFR4EIF2AK4JAK2JAK3EGFR | |
| SCHEMBL1353780 | 0.82 | EIF2AK4 (0.60) | FGFR4EIF2AK4JAK2JAK3EGFR | |
| SCHEMBL1355792 | 0.82 | EIF2AK4 (0.57) | FGFR4EIF2AK4JAK2JAK3BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110281821-A9 | Modulators of Mitotic Kinases | BIOGEN IDEC MA INC. (US) | 2011-11-17 | — | — | US | claimed |
| US-20100249067-A1 | Modulators of Mitotic Kinases | BIOGEN IDEC MA INC. (US) | 2010-09-30 | — | — | US | claimed |
| US-20110281821-A9 | Modulators of Mitotic Kinases | BIOGEN IDEC MA INC. (US) | 2011-11-17 | — | — | US | disclosed |
| US-20100249067-A1 | Modulators of Mitotic Kinases | BIOGEN IDEC MA INC. (US) | 2010-09-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100249067-A1 | Modulators of Mitotic Kinases | BUB1, BUB1B, CDK1 | FGFR4 1543/4885EIF2AK4 791/4885JAK2 1365/4885 |
| US-20110281821-A9 | Modulators of Mitotic Kinases | BUB1, BUB1B, CDK1 | FGFR4 1543/4885EIF2AK4 791/4885JAK2 1365/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.