Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK1 | P06493 | 5/20 | 0.57 |
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.56 |
| ▸ | CDK2 | P24941 | 6/20 | 0.55 |
| ▸ | CCNE1 | P24864 | 5/20 | 0.55 |
| ▸ | CDK5 | Q00535 | 5/20 | 0.55 |
| ▸ | CDK5R1 | Q15078 | 5/20 | 0.55 |
| ▸ | CCNT1 | O60563 | 4/20 | 0.55 |
| ▸ | CDK9 | P50750 | 4/20 | 0.55 |
| ▸ | CDK7 | P50613 | 2/20 | 0.55 |
| ▸ | CCNH | P51946 | 2/20 | 0.55 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.47 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.46 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.46 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.46 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1354599 | 0.89 | CDK1 (0.72) | CDK1YTHDC1CDK2CCNE1CDK5 | |
| SCHEMBL5192872 | 0.84 | CDK1 (0.79) | CDK1CDK2CCNE1CDK5CDK5R1 | |
| SCHEMBL1354515 | 0.84 | YTHDC1 (0.69) | CDK1YTHDC1CDK2CCNE1CDK5 | |
| SCHEMBL1355025 | 0.83 | CDK1 (0.70) | CDK1YTHDC1CDK2CCNE1CDK5 | |
| SCHEMBL1354969 | 0.81 | CDK2 (0.83) | CDK1CDK2CCNE1CDK5CDK5R1 | |
| SCHEMBL1355219 | 0.78 | YTHDC1 (0.71) | CDK1YTHDC1CDK2HDAC1HDAC3 | |
| SCHEMBL5196618 | 0.78 | CDK1 (0.52) | CDK1YTHDC1CDK2CDK5CDK5R1 | |
| SCHEMBL5193482 | 0.78 | CDK5 (0.60) | CDK1YTHDC1CDK2CCNE1CDK5 | |
| SCHEMBL1352692 | 0.77 | CDK1 (0.63) | CDK1YTHDC1CDK2CCNE1ADORA3 | |
| SCHEMBL5193584 | 0.77 | CDK1 (0.61) | CDK1ADORA3ADORA1ADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9023857-B2 | Substituted 6-(2-aminobenzylamino)purine derivatives, their use as medicaments and preparations containing these compounds | UNIVERZITA PALACKEHO V OLOMOUCI (CZ) | 2015-05-05 | — | — | US | disclosed |
| EP-2391626-B1 | SUBSTITUTED 6-(2-AMINOBENZYLAMINO)PURINE DERIVATIVES, THEIR USE AS MEDICAMENTS AND PREPARATIONS CONTAINING THESE COMPOUNDS | Univerzita Palackého v Olomouci (CZ) | 2014-10-01 | — | — | EP | disclosed |
| EP-2391626-A2 | SUBSTITUTED 6-(2-AMINOBENZYLAMINO)PURINE DERIVATIVES, THEIR USE AS MEDICAMENTS AND PREPARATIONS CONTAINING THESE COMPOUNDS | Univerzita Palackého v Olomouci (CZ) | 2011-12-07 | — | — | EP | disclosed |
| US-20110287111-A1 | SUBSTITUTED 6-(2-AMINOBENZYLAMINO)PURINE DERIVATIVES, THEIR USE AS MEDICAMENTS AND PREPARATIONS CONTAINING THESE COMPOUNDS | UNIVERZITA PALACKEHO V OLOMOUCI (CZ) | 2011-11-24 | — | — | US | disclosed |
| WO-2010085924-A2 | SUBSTITUTED 6-(2-AMINOBENZYLAMINO)PURINE DERIVATIVES, THEIR USE AS MEDICAMENTS AND PREPARATIONS CONTAINING THESE COMPOUNDS | UNIVERZITA PALACKEHO V OLOMOUCI (CZ) | 2010-08-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110287111-A1 | SUBSTITUTED 6-(2-AMINOBENZYLAMINO)PURINE DERIVATIVES, THEIR USE AS MEDICAMENTS AND PREPARATIONS CONTAINING THESE COMPOUNDS | CDK6, CCNI, CDK2 | CDK1 4/4885YTHDC1 1693/4885CDK2 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.