Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 8/20 | 0.47 |
| ▸ | MEN1 | O00255 | 7/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12847215 | 0.87 | BRD4 (0.39) | KMT2AMEN1MAPTNPSR1KDM4E | |
| SCHEMBL12789710 | 0.87 | KMT2A (0.49) | KMT2AMEN1MAPTNPSR1ALDH1A1 | |
| SCHEMBL12789722 | 0.85 | MEN1 (0.45) | KMT2AMEN1MAPTNPSR1KDM4E | |
| SCHEMBL12846922 | 0.83 | MEN1 (0.39) | KMT2AMEN1MAPTKDM4EHSD17B10 | |
| SCHEMBL12789754 | 0.81 | CYP2D6 (0.47) | KMT2AMEN1MAPTNPSR1POLB | |
| SCHEMBL12789762 | 0.81 | CYP2D6 (0.47) | KMT2AMEN1MAPTNPSR1POLB | |
| SCHEMBL12789709 | 0.80 | MEN1 (0.41) | KMT2AMEN1MAPTNPSR1KDM4E | |
| SCHEMBL12789719 | 0.80 | KMT2A (0.41) | KMT2AMEN1MAPTNPSR1KDM4E | |
| SCHEMBL12789743 | 0.80 | MEN1 (0.41) | KMT2AMEN1MAPTNPSR1KDM4E | |
| SCHEMBL12789714 | 0.79 | KMT2A (0.40) | KMT2AMEN1MAPTNPSR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2297117-B1 | BICYCLIC HETEROCYCLE DERIVATIVES AND USE THEREOF AS GPR119 MODULATORS | MERCK SHARP & DOHME (US) | 2012-10-31 | — | — | EP | disclosed |