Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 4/20 | 0.47 |
| ▸ | GHSR | Q92847 | 3/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | CASR | P41180 | 1/20 | 0.38 |
| ▸ | GRK2 | P25098 | 1/20 | 0.38 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.38 |
| ▸ | DHODH | Q02127 | 2/20 | 0.37 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.37 |
| ▸ | F2RL1 | P55085 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12789762 | 1.00 | CYP2D6 (0.47) | CYP2D6GHSRKCNH2MEN1KMT2A | |
| SCHEMBL12789106 | 0.91 | CYP2D6 (0.44) | CYP2D6GHSRKCNH2MEN1KMT2A | |
| SCHEMBL12789093 | 0.90 | CYP2D6 (0.45) | CYP2D6GHSRKCNH2MEN1KMT2A | |
| SCHEMBL12789087 | 0.90 | CYP2D6 (0.45) | CYP2D6GHSRKCNH2MEN1KMT2A | |
| SCHEMBL12789763 | 0.84 | CYP2D6 (0.48) | CYP2D6GHSRKCNH2POLBHRH3 | |
| SCHEMBL12789766 | 0.84 | CYP2D6 (0.48) | CYP2D6GHSRKCNH2POLBHRH3 | |
| SCHEMBL12789709 | 0.83 | MEN1 (0.41) | MEN1KMT2AMAPTNPSR1POLB | |
| SCHEMBL12789743 | 0.83 | MEN1 (0.41) | MEN1KMT2AMAPTNPSR1POLB | |
| SCHEMBL12788743 | 0.81 | CYP2D6 (0.48) | CYP2D6GHSRKCNH2POLBHRH3 | |
| SCHEMBL13564427 | 0.81 | KMT2A (0.47) | MEN1KMT2AMAPTNPSR1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110065671-A1 | BICYCLIC HETEROCYCLE DERIVATIVES AND USE THEREOF AS GPR119 MODULATORS | MERCK SHARP & DOHME CORP. | 2011-03-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110065671-A1 | BICYCLIC HETEROCYCLE DERIVATIVES AND USE THEREOF AS GPR119 MODULATORS | GPR119, GPR39, GPR65 | CYP2D6 1548/4885GHSR 87/4885KCNH2 1907/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.