Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA1 | P42261 | 3/20 | 0.54 |
| ▸ | GRIA4 | P48058 | 6/20 | 0.54 |
| ▸ | NPY5R | Q15761 | 6/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13565845 | 1.00 | GRIA1 (0.54) | GRIA1GRIA4NPY5RHDAC1HDAC2 | |
| SCHEMBL13566030 | 0.91 | GRIA1 (0.61) | GRIA1GRIA4NPY5RALDH1A1KDM4E | |
| SCHEMBL11935071 | 0.89 | GRIA1 (0.54) | GRIA1GRIA4NPY5RALDH1A1KDM4E | |
| SCHEMBL13564797 | 0.85 | GRIA1 (0.50) | GRIA1NPY5RHDAC1HDAC2 | |
| SCHEMBL13564803 | 0.84 | GRIA2 (0.57) | GRIA1GRIA4NPY5R | |
| SCHEMBL11935811 | 0.84 | GRIA1 (0.49) | GRIA1GRIA4NPY5RALDH1A1MAPT | |
| SCHEMBL13565179 | 0.84 | GRIA1 (0.49) | GRIA1GRIA4NPY5RALDH1A1LMNA | |
| SCHEMBL17090457 | 0.84 | ALDH1A1 (0.51) | GRIA1NPY5RHDAC1ALDH1A1KDM4E | |
| SCHEMBL13564795 | 0.84 | ALDH1A1 (0.49) | GRIA1GRIA4NPY5RALDH1A1KDM4E | |
| SCHEMBL13564968 | 0.84 | GRIA1 (0.59) | GRIA1GRIA4NPY5RALDH1A1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9139518-B2 | Amine derivative having NPY Y5 receptor antagonistic activity | SHIONOGI & CO., LTD. (JP) | 2015-09-22 | — | — | US | disclosed |
| US-8299265-B2 | Amine derivatives having NPY Y5 receptor antagonistic activity and the uses thereof | SHIONOGI & CO., LTD. (JP) | 2012-10-30 | — | — | US | disclosed |