Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPY5R | Q15761 | 7/20 | 0.41 |
| ▸ | GRIA1 | P42261 | 3/20 | 0.40 |
| ▸ | EDNRA | P25101 | 5/20 | 0.34 |
| ▸ | EDNRB | P24530 | 4/20 | 0.34 |
| ▸ | TTK | P33981 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 2/20 | 0.33 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.33 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.33 |
| ▸ | LIPC | P11150 | 1/20 | 0.33 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13565222 | 0.88 | GRIA4 (0.34) | NPY5RGRIA1EDNRAEDNRBTTK | |
| SCHEMBL13565650 | 0.85 | TTK (0.37) | EDNRAEDNRBTTKHTR1AADRA1D | |
| SCHEMBL10115480 | 0.85 | SMN1; SMN2 (0.42) | — | |
| SCHEMBL13565516 | 0.84 | GRIA1 (0.44) | NPY5RGRIA1EDNRAEDNRBLIPC | |
| SCHEMBL11935700 | 0.81 | FERMT2 (0.40) | TTKHTR1AADRA1DADRA1AADRA1B | |
| SCHEMBL13565290 | 0.79 | TTK (0.36) | EDNRAEDNRBTTKLIPCLIPG | |
| SCHEMBL17090484 | 0.78 | EDNRA (0.35) | EDNRAEDNRBTTK | |
| SCHEMBL13565946 | 0.78 | PPARA (0.37) | EDNRAEDNRB | |
| SCHEMBL11935710 | 0.78 | TTK (0.35) | EDNRAEDNRBTTKHTR1AADRA1D | |
| SCHEMBL17090429 | 0.75 | GRIA2 (0.41) | TTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9139518-B2 | Amine derivative having NPY Y5 receptor antagonistic activity | SHIONOGI & CO., LTD. (JP) | 2015-09-22 | — | — | US | disclosed |
| US-8299265-B2 | Amine derivatives having NPY Y5 receptor antagonistic activity and the uses thereof | SHIONOGI & CO., LTD. (JP) | 2012-10-30 | — | — | US | disclosed |