Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RECQL | P46063 | 2/20 | 0.48 |
| ▸ | NPY5R | Q15761 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | HTT | P42858 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.40 |
| ▸ | HPGD | P15428 | 5/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13565008 | 0.93 | LMNA (0.53) | RECQLLMNAALDH1A1HPGDPOLB | |
| SCHEMBL17090080 | 0.85 | RECQL (0.48) | RECQLLMNAMAPTHTTSMN1; SMN2 | |
| SCHEMBL13564758 | 0.85 | RECQL (0.48) | RECQLLMNAMAPTHTTSMN1; SMN2 | |
| SCHEMBL10114046 | 0.84 | RECQL (0.47) | RECQLLMNAMAPTHTTSMN1; SMN2 | |
| SCHEMBL13564826 | 0.84 | MAPT (0.41) | NPY5RLMNAMAPTHTTSMN1; SMN2 | |
| SCHEMBL13564755 | 0.79 | LMNA (0.53) | RECQLLMNAALDH1A1HPGDPOLB | |
| SCHEMBL17090084 | 0.79 | LMNA (0.53) | RECQLLMNAALDH1A1HPGDPOLB | |
| SCHEMBL10114049 | 0.79 | LMNA (0.52) | LMNAALDH1A1HPGDPOLBCYP1A2 | |
| SCHEMBL13438701 | 0.77 | RECQL (0.46) | RECQLLMNAMAPTHTTSMN1; SMN2 | |
| SCHEMBL11934821 | 0.77 | RECQL (0.46) | RECQLLMNAMAPTHTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9139518-B2 | Amine derivative having NPY Y5 receptor antagonistic activity | SHIONOGI & CO., LTD. (JP) | 2015-09-22 | — | — | US | disclosed |
| US-8299265-B2 | Amine derivatives having NPY Y5 receptor antagonistic activity and the uses thereof | SHIONOGI & CO., LTD. (JP) | 2012-10-30 | — | — | US | disclosed |