Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA1 | P42261 | 3/20 | 0.41 |
| ▸ | NPY5R | Q15761 | 8/20 | 0.36 |
| ▸ | BRD4 | O60885 | 4/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13565630 | 0.89 | GRIA1 (0.41) | GRIA1NPY5RBRD4HTR1A | |
| SCHEMBL13565225 | 0.86 | GRIA1 (0.39) | GRIA1NPY5RBRD4HTR1AALDH1A1 | |
| SCHEMBL13565151 | 0.85 | NPY5R (0.36) | NPY5RBRD4ALDH1A1TSHR | |
| SCHEMBL10115306 | 0.85 | GAA (0.41) | GRIA1HTR1AALDH1A1TSHR | |
| SCHEMBL17090056 | 0.83 | GRIA1 (0.41) | GRIA1NPY5RBRD4HTR1A | |
| SCHEMBL13564993 | 0.83 | GRIA1 (0.41) | GRIA1NPY5RBRD4HTR1A | |
| SCHEMBL11935053 | 0.82 | MAPT (0.44) | GRIA1NPY5RBRD4HTR1A | |
| SCHEMBL11941099 | 0.82 | MAPT (0.44) | GRIA1NPY5RBRD4HTR1A | |
| SCHEMBL17090211 | 0.82 | MAPT (0.44) | GRIA1NPY5RBRD4HTR1A | |
| SCHEMBL17090054 | 0.82 | GRIA1 (0.40) | GRIA1NPY5RBRD4HTR1AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9139518-B2 | Amine derivative having NPY Y5 receptor antagonistic activity | SHIONOGI & CO., LTD. (JP) | 2015-09-22 | — | — | US | disclosed |
| US-8299265-B2 | Amine derivatives having NPY Y5 receptor antagonistic activity and the uses thereof | SHIONOGI & CO., LTD. (JP) | 2012-10-30 | — | — | US | disclosed |