Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPY5R | Q15761 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 4/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17090269 | 0.89 | NPY5R (0.36) | NPY5RBRD4CNR2HDAC6KDM4E | |
| SCHEMBL13565146 | 0.89 | NPY5R (0.36) | NPY5RBRD4CNR2HDAC6KDM4E | |
| SCHEMBL11935544 | 0.86 | KDM4E (0.38) | NPY5RBRD4L3MBTL1CNR2ALDH1A1 | |
| SCHEMBL13565632 | 0.85 | GRIA1 (0.41) | NPY5RBRD4ALDH1A1TSHR | |
| SCHEMBL10115048 | 0.85 | GAA (0.41) | HDAC6ALDH1A1TSHRMEN1KMT2A | |
| SCHEMBL11935626 | 0.83 | BRD4 (0.36) | NPY5RBRD4L3MBTL1HDAC6ALDH1A1 | |
| SCHEMBL11941031 | 0.83 | BRD4 (0.36) | NPY5RBRD4L3MBTL1HDAC6ALDH1A1 | |
| SCHEMBL11940986 | 0.82 | MAPT (0.44) | NPY5RBRD4CNR2MAPT | |
| SCHEMBL17090267 | 0.82 | MAPT (0.44) | NPY5RBRD4CNR2MAPT | |
| SCHEMBL11934925 | 0.82 | MAPT (0.44) | NPY5RBRD4CNR2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9139518-B2 | Amine derivative having NPY Y5 receptor antagonistic activity | SHIONOGI & CO., LTD. (JP) | 2015-09-22 | — | — | US | disclosed |
| US-8299265-B2 | Amine derivatives having NPY Y5 receptor antagonistic activity and the uses thereof | SHIONOGI & CO., LTD. (JP) | 2012-10-30 | — | — | US | disclosed |