Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.34 |
| ▸ | NPY2R | P49146 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17090414 | 1.00 | KDM4E (0.38) | KDM4ELMNAGAAHPGDMAPK1 | |
| SCHEMBL13565736 | 0.89 | USP30 (0.39) | KDM4ELMNAGAACNR2SMN1; SMN2 | |
| SCHEMBL11935544 | 0.89 | KDM4E (0.38) | KDM4ELMNAGAACNR2SMN1; SMN2 | |
| SCHEMBL11935738 | 0.86 | GRIA1 (0.38) | KDM4ELMNAGAAHPGDMAPK1 | |
| SCHEMBL11941197 | 0.86 | GRIA1 (0.38) | KDM4ELMNAGAAHPGDMAPK1 | |
| SCHEMBL10133519 | 0.86 | NPC1 (0.48) | KDM4ELMNAGAASMN1; SMN2TSHR | |
| SCHEMBL10115011 | 0.86 | NPC1 (0.48) | KDM4ELMNAGAASMN1; SMN2TSHR | |
| SCHEMBL11940986 | 0.83 | MAPT (0.44) | CNR2NPY5RBRD4MAPT | |
| SCHEMBL17090267 | 0.83 | MAPT (0.44) | CNR2NPY5RBRD4MAPT | |
| SCHEMBL11934925 | 0.83 | MAPT (0.44) | CNR2NPY5RBRD4MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8299265-B2 | Amine derivatives having NPY Y5 receptor antagonistic activity and the uses thereof | SHIONOGI & CO., LTD. (JP) | 2012-10-30 | — | — | US | disclosed |