Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.65 |
| ▸ | MEN1 | O00255 | 4/20 | 0.65 |
| ▸ | LMNA | P02545 | 4/20 | 0.65 |
| ▸ | PKM | P14618 | 1/20 | 0.65 |
| ▸ | POLB | P06746 | 4/20 | 0.64 |
| ▸ | HTT | P42858 | 6/20 | 0.57 |
| ▸ | GAA | P10253 | 4/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.56 |
| ▸ | HPGD | P15428 | 2/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.56 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.56 |
| ▸ | MGAM | O43451 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4076943 | 0.94 | POLB (0.60) | MAPTKMT2AMEN1LMNAPKM | |
| SCHEMBL13568891 | 0.93 | KMT2A (0.66) | MAPTKMT2AMEN1LMNAPKM | |
| SCHEMBL13569129 | 0.88 | POLB (0.54) | MAPTKMT2AMEN1LMNAPKM | |
| SCHEMBL13568979 | 0.87 | SIRT1 (0.59) | MAPTKMT2AMEN1LMNAPKM | |
| SCHEMBL7261114 | 0.86 | MAPT (0.57) | MAPTKMT2AMEN1LMNAPKM | |
| SCHEMBL12964951 | 0.85 | GAA (0.53) | MAPTKMT2AMEN1LMNAPKM | |
| SCHEMBL13569038 | 0.85 | POLB (0.70) | MAPTKMT2AMEN1LMNAPOLB | |
| SCHEMBL13568994 | 0.83 | MGAM (0.71) | MAPTKMT2AMEN1LMNAPKM | |
| SCHEMBL13569114 | 0.83 | MGAM (0.71) | MAPTKMT2AMEN1POLBGAA | |
| SCHEMBL7261077 | 0.83 | MAPT (0.54) | MAPTKMT2AMEN1LMNAPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009155362-A1 | SMALL MOLECULE HEMATOPOIETIC GROWTH FACTOR MIMETIC COMPOUNDS AND THEIR USES | LIGAND PHARMACEUTICALS INC. (US) | 2009-12-23 | — | — | WO | disclosed |