Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1I | Q9P0X4 | 12/20 | 0.59 |
| ▸ | KCNH2 | Q12809 | 12/20 | 0.59 |
| ▸ | CACNA1H | O95180 | 5/20 | 0.57 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4269884 | 0.93 | CACNA1I (0.65) | CACNA1IKCNH2CACNA1HCACNA1GCYP2D6 | |
| SCHEMBL4270502 | 0.86 | CACNA1I (0.69) | CACNA1IKCNH2CACNA1HCACNA1GCYP2D6 | |
| SCHEMBL4274643 | 0.85 | CACNA1H (0.77) | CACNA1IKCNH2CACNA1HCACNA1GCYP2D6 | |
| SCHEMBL19112531 | 0.84 | CACNA1I (0.66) | CACNA1IKCNH2CACNA1HCACNA1GCYP2D6 | |
| SCHEMBL13569701 | 0.83 | CACNA1I (0.55) | CACNA1IKCNH2CACNA1HCACNA1G | |
| SCHEMBL14769934 | 0.83 | CACNA1I (0.70) | CACNA1IKCNH2CACNA1HCACNA1GCYP2D6 | |
| SCHEMBL4278341 | 0.83 | KCNH2 (0.61) | CACNA1IKCNH2CACNA1HCACNA1GCYP2D6 | |
| SCHEMBL4277443 | 0.83 | CACNA1I (0.64) | CACNA1IKCNH2CACNA1HCACNA1G | |
| SCHEMBL4284353 | 0.83 | CACNA1I (0.61) | CACNA1IKCNH2CACNA1HCACNA1GCYP2D6 | |
| SCHEMBL26082108 | 0.82 | CACNA1I (0.64) | CACNA1IKCNH2CACNA1HCACNA1GCYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3189839-B1 | N-PIPERIDINYL ACETAMIDE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS | PRAXIS PREC MEDICINES INC (US) | 2020-05-20 | — | — | EP | disclosed |
| EP-2300007-B1 | N-PIPERIDINYL ACETAMIDE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS | TARO PHARMACEUTICALS INC (CA) | 2018-04-18 | — | — | EP | disclosed |
| WO-2009146540-A1 | N-PIPERIDINYL ACETAMIDE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS | NEUROMED PHARMACEUTICALS LTD (CA) | 2009-12-10 | — | — | WO | disclosed |