Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1I | Q9P0X4 | 9/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 9/20 | 0.55 |
| ▸ | CACNA1H | O95180 | 4/20 | 0.51 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.40 |
| ▸ | CCR2 | P41597 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4284041 | 0.92 | CACNA1I (0.58) | CACNA1IKCNH2CACNA1HCACNA1GCCR2 | |
| SCHEMBL13569815 | 0.92 | CACNA1I (0.60) | CACNA1IKCNH2CACNA1HCACNA1GMCHR1 | |
| SCHEMBL20056293 | 0.88 | CACNA1I (0.55) | CACNA1IKCNH2CACNA1HCACNA1GMCHR1 | |
| SCHEMBL4277343 | 0.85 | KCNH2 (0.54) | CACNA1IKCNH2CACNA1HCACNA1GALDH1A1 | |
| SCHEMBL13569693 | 0.83 | CACNA1I (0.59) | CACNA1IKCNH2CACNA1HCACNA1G | |
| SCHEMBL4280554 | 0.83 | CACNA1I (0.64) | CACNA1IKCNH2CACNA1HCACNA1GMCHR1 | |
| SCHEMBL26082029 | 0.81 | CACNA1H (0.60) | CACNA1IKCNH2CACNA1HCACNA1GCCR2 | |
| SCHEMBL4276850 | 0.81 | CACNA1I (0.61) | CACNA1IKCNH2CACNA1HCACNA1GALDH1A1 | |
| SCHEMBL4274643 | 0.80 | CACNA1H (0.77) | CACNA1IKCNH2CACNA1HCACNA1G | |
| SCHEMBL21952106 | 0.80 | KCNH2 (0.60) | CACNA1IKCNH2CACNA1HCACNA1GCCR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3189839-A1 | N-PIPERIDINYL ACETAMIDE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS | Taro Pharmaceuticals Inc. (CA) | 2017-07-12 | — | — | EP | disclosed |
| WO-2009146540-A1 | N-PIPERIDINYL ACETAMIDE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS | NEUROMED PHARMACEUTICALS LTD (CA) | 2009-12-10 | — | — | WO | disclosed |