Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 7/20 | 0.41 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.40 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.40 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.40 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.40 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.40 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.40 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.40 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13585559 | 0.98 | HDAC1 (0.41) | ALDH1A1HDAC1BMPR1BBMPR1ATGFBR1 | |
| SCHEMBL13569896 | 0.94 | HDAC1 (0.42) | ALDH1A1HDAC1USP2HDAC3HDAC4 | |
| SCHEMBL4233210 | 0.92 | KDM4E (0.46) | ALDH1A1HDAC1BMPR1BBMPR1ATGFBR1 | |
| SCHEMBL4229502 | 0.90 | KDM4E (0.43) | ALDH1A1HDAC1BMPR1BBMPR1ATGFBR1 | |
| SCHEMBL2382243 | 0.90 | HDAC1 (0.43) | ALDH1A1HDAC1BMPR1BBMPR1ATGFBR1 | |
| SCHEMBL13570021 | 0.89 | ALDH1A1 (0.40) | ALDH1A1USP2KDM4ENPC1RAB9A | |
| SCHEMBL13569895 | 0.88 | HDAC1 (0.42) | HDAC1USP2HDAC3HDAC2NAMPT | |
| SCHEMBL13585749 | 0.88 | USP2 (0.42) | ALDH1A1HDAC1USP2HDAC3HDAC2 | |
| SCHEMBL13585756 | 0.88 | HDAC1 (0.41) | ALDH1A1HDAC1BMPR1BBMPR1ATGFBR1 | |
| SCHEMBL4222453 | 0.87 | USP2 (0.45) | ALDH1A1HDAC1USP2KDM4EHDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2135620-A1 | OCULAR HYPOTENSIVE AGENT COMPRISING COMPOUND CAPABLE OF INHIBITING HISTONE DEACETYLASE AS ACTIVE INGREDIENT | Santen Pharmaceutical Co., Ltd (JP) | 2009-12-23 | — | — | EP | disclosed |
| EP-2133339-A1 | NOVEL (2-AMINOPHENYL)PYRIDINECARBOXAMIDE DERIVATIVE HAVING UREA STRUCTURE | Santen Pharmaceutical Co., Ltd (JP) | 2009-12-16 | — | — | EP | disclosed |