Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 4/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.43 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.43 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CDC42BPA | Q5VT25 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.39 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3235242 | 0.92 | ROCK2 (0.46) | ROCK2HDAC1HDAC3HDAC2HDAC10 | |
| SCHEMBL4228660 | 0.86 | HDAC1 (0.59) | ROCK2HDAC1HDAC3HDAC2HDAC10 | |
| SCHEMBL3219355 | 0.84 | SMN1; SMN2 (0.43) | ROCK2HDAC1HDAC3HDAC2HDAC10 | |
| SCHEMBL3215193 | 0.82 | ROCK2 (0.43) | ROCK2HDAC1HDAC3HDAC2HDAC10 | |
| SCHEMBL3262920 | 0.78 | ROCK2 (0.50) | ROCK2HDAC1ROCK1CYP3A4CYP2D6 | |
| SCHEMBL13585670 | 0.78 | HDAC1 (0.57) | HDAC1HDAC3HDAC2HDAC10NCOR2 | |
| SCHEMBL3230782 | 0.78 | HDAC1 (0.39) | ROCK2HDAC1HDAC3HDAC2HDAC10 | |
| SCHEMBL3232699 | 0.77 | NPC1 (0.40) | HDAC1KDM4ESMN1; SMN2KMT2AMEN1 | |
| SCHEMBL13585924 | 0.76 | HDAC1 (0.41) | HDAC1HDAC3HDAC2HDAC10NCOR2 | |
| SCHEMBL4224463 | 0.75 | HDAC1 (0.51) | HDAC1HDAC3HDAC2HDAC10NCOR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2133339-A1 | NOVEL (2-AMINOPHENYL)PYRIDINECARBOXAMIDE DERIVATIVE HAVING UREA STRUCTURE | Santen Pharmaceutical Co., Ltd (JP) | 2009-12-16 | — | — | EP | disclosed |