Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 15/20 | 0.68 |
| ▸ | ATM | Q13315 | 1/20 | 0.59 |
| ▸ | HTT | P42858 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | GLA | P06280 | 1/20 | 0.57 |
| ▸ | PKM | P14618 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13570566 | 1.00 | TRPA1 (0.68) | TRPA1ATMHTTALDH1A1LMNA | |
| SCHEMBL894178 | 0.92 | TRPA1 (0.68) | TRPA1ATMHTTALDH1A1LMNA | |
| SCHEMBL13737904 | 0.92 | TRPA1 (0.62) | TRPA1ATMHTTALDH1A1LMNA | |
| SCHEMBL13738656 | 0.92 | TRPA1 (0.62) | TRPA1ATMHTTALDH1A1LMNA | |
| SCHEMBL13738653 | 0.92 | TRPA1 (0.62) | TRPA1ATMHTTALDH1A1LMNA | |
| SCHEMBL13570550 | 0.88 | TRPA1 (0.64) | TRPA1ATMHTTALDH1A1LMNA | |
| SCHEMBL13570549 | 0.88 | TRPA1 (0.64) | TRPA1ATMHTTALDH1A1LMNA | |
| SCHEMBL20113124 | 0.87 | TRPA1 (0.78) | TRPA1HTTALDH1A1LMNAGLA | |
| SCHEMBL893791 | 0.85 | TRPA1 (0.63) | TRPA1ATMHTTALDH1A1LMNA | |
| SCHEMBL893466 | 0.84 | TRPA1 (0.85) | TRPA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2520566-A1 | New Pharmaceutical Compounds | Orion Corporation (FI) | 2012-11-07 | — | — | EP | claimed |
| WO-2012152983-A1 | PHENYL- SULFONYL DERIVATIVES AS MEDIATORS OF TRPA1 RECEPTOR ACTIVITY FOR THE TREATMENT OF PAIN | ORION CORPORATION (FI) | 2012-11-15 | — | — | WO | disclosed |
| EP-2520566-A1 | New Pharmaceutical Compounds | Orion Corporation (FI) | 2012-11-07 | — | — | EP | disclosed |