Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDR1 | Q08345 | 1/20 | 0.56 |
| ▸ | RAD52 | P43351 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 2/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | ATM | Q13315 | 1/20 | 0.54 |
| ▸ | RAF1 | P04049 | 1/20 | 0.54 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2278943 | 0.91 | DDR1 (0.65) | DDR1RAD52ATMRAF1MAPK14 | |
| SCHEMBL2280488 | 0.79 | DDR1 (0.58) | DDR1RAD52HTTMAPK1ATM | |
| SCHEMBL2282782 | 0.78 | DDR1 (0.78) | DDR1RAD52ATMRAF1MAPK14 | |
| SCHEMBL2280193 | 0.78 | RAD52 (0.75) | DDR1RAD52HTTMAPK1ATM | |
| SCHEMBL17208738 | 0.75 | RAD52 (0.71) | DDR1RAD52HTTMAPK1ATM | |
| SCHEMBL19986849 | 0.74 | RAD52 (0.81) | DDR1RAD52HTTMAPK1ATM | |
| SCHEMBL2276365 | 0.74 | DDR1 (0.70) | DDR1RAD52RAF1MAPK14 | |
| SCHEMBL2226738 | 0.74 | RAD52 (0.82) | DDR1RAD52HTTMAPK1ATM | |
| SCHEMBL14702344 | 0.73 | DDR1 (0.83) | DDR1RAD52ATMRAF1MAPK14 | |
| SCHEMBL2280492 | 0.73 | DDR1 (0.46) | DDR1RAD52HTTRAF1MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2519517-A2 | TYPE II RAF KINASE INHIBITORS | Dana-Farber Cancer Institute, Inc. (US) | 2012-11-07 | — | — | EP | disclosed |