Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAD52 | P43351 | 1/20 | 0.81 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.64 |
| ▸ | NR2C2 | P49116 | 3/20 | 0.61 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.61 |
| ▸ | FES | P07332 | 1/20 | 0.61 |
| ▸ | HCK | P08631 | 1/20 | 0.61 |
| ▸ | FER | P16591 | 1/20 | 0.61 |
| ▸ | GCK | P35557 | 1/20 | 0.61 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.61 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.61 |
| ▸ | BTK | Q06187 | 2/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.59 |
| ▸ | HTT | P42858 | 1/20 | 0.59 |
| ▸ | ATM | Q13315 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17208696 | 0.94 | RAD52 (0.80) | RAD52DDR1NR2C2BTKMAPK1 | |
| SCHEMBL2226738 | 0.93 | RAD52 (0.82) | RAD52DDR1NR2C2BTKMAPK1 | |
| SCHEMBL17208720 | 0.92 | RAD52 (0.95) | RAD52DDR1NR2C2BTKMAPK1 | |
| SCHEMBL17208642 | 0.92 | RAD52 (0.79) | RAD52DDR1NR2C2HCKBTK | |
| SCHEMBL22457642 | 0.91 | RAD52 (0.78) | RAD52DDR1NR2C2BTKMAPK1 | |
| SCHEMBL2280193 | 0.90 | RAD52 (0.75) | RAD52DDR1NR2C2HCKGCK | |
| SCHEMBL2228555 | 0.90 | RAD52 (0.84) | RAD52DDR1NR2C2BTKMAPK1 | |
| SCHEMBL17208738 | 0.87 | RAD52 (0.71) | RAD52DDR1NR2C2MAP3K7HCK | |
| SCHEMBL19986863 | 0.86 | RAD52 (0.71) | RAD52DDR1NR2C2HCK | |
| SCHEMBL16588513 | 0.86 | RAD52 (0.71) | RAD52DDR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2937345-B1 | TYPE II RAF KINASE INHIBITORS | DANA FARBER CANCER INST INC (US) | 2018-03-21 | — | — | EP | disclosed |