Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | PTGER4 | P35408 | 4/20 | 0.39 |
| ▸ | PTGER3 | P43115 | 4/20 | 0.39 |
| ▸ | PTGER2 | P43116 | 4/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | SCN1A | P35498 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16509685 | 0.88 | CHRM2 (0.43) | PTGER4PTGER3PTGER2KMT2ACYP1A2 | |
| SCHEMBL12298852 | 0.78 | PTGER4 (0.52) | ALDH1A1GAAPTGER4PTGER3PTGER2 | |
| SCHEMBL12993185 | 0.78 | PTGER4 (0.52) | ALDH1A1GAAPTGER4PTGER3PTGER2 | |
| SCHEMBL13573005 | 0.77 | KDM4E (0.38) | ALDH1A1PTGER4PTGER3PTGER2SMN1; SMN2 | |
| SCHEMBL635958 | 0.76 | PTGER4 (0.40) | PTGER4PTGER3PTGER2KMT2ACHRM2 | |
| SCHEMBL13572913 | 0.74 | PTGER4 (0.41) | ALDH1A1PTGER4PTGER3PTGER2KMT2A | |
| SCHEMBL1865254 | 0.71 | PTGER4 (0.52) | ALDH1A1GAAPTGER4PTGER3PTGER2 | |
| SCHEMBL10750938 | 0.70 | PTGER4 (0.57) | GAAPTGER4PTGER3PTGER2KMT2A | |
| SCHEMBL10772975 | 0.70 | PTGER4 (0.38) | GAAPTGER4PTGER3PTGER2KMT2A | |
| SCHEMBL14839577 | 0.69 | PTGER4 (0.40) | ALDH1A1PTGER4PTGER3PTGER2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110306597-A1 | Nicotinamide Derivatives | CRAWFORTH JAMES MICHAEL (GB) | 2011-12-15 | — | — | US | disclosed |
| WO-2009153721-A1 | NICOTINAMIDE DERIVATIVES | PFIZER LIMITED (GB) | 2009-12-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110306597-A1 | Nicotinamide Derivatives | NNT, NAMPT, NQO1 | ALDH1A1 172/4885GAA 887/4885PTGER4 722/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.