Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 5/20 | 0.44 |
| ▸ | DYRK1A | Q13627 | 5/20 | 0.44 |
| ▸ | WNT1 | P04628 | 3/20 | 0.40 |
| ▸ | MAP4K1 | Q92918 | 2/20 | 0.38 |
| ▸ | CDK2 | P24941 | 5/20 | 0.38 |
| ▸ | CCNB2 | O95067 | 3/20 | 0.38 |
| ▸ | CDK1 | P06493 | 3/20 | 0.38 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.38 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.38 |
| ▸ | CDK5R1 | Q15078 | 3/20 | 0.38 |
| ▸ | CCNB3 | Q8WWL7 | 3/20 | 0.38 |
| ▸ | CCNE2 | O96020 | 3/20 | 0.38 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.38 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.38 |
| ▸ | CDK9 | P50750 | 2/20 | 0.38 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.38 |
| ▸ | AXL | P30530 | 2/20 | 0.38 |
| ▸ | MAP4K3 | Q8IVH8 | 1/20 | 0.37 |
| ▸ | TTK | P33981 | 4/20 | 0.37 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13574026 | 0.90 | GSK3B (0.43) | GSK3BDYRK1AWNT1MAP4K1CDK2 | |
| SCHEMBL13336128 | 0.90 | GSK3B (0.43) | GSK3BDYRK1AWNT1MAP4K1CDK2 | |
| SCHEMBL13336219 | 0.88 | GSK3B (0.42) | GSK3BDYRK1AWNT1MAP4K1CDK2 | |
| SCHEMBL13573972 | 0.84 | MAP4K1 (0.44) | GSK3BDYRK1AWNT1MAP4K1TYRO3 | |
| SCHEMBL13573976 | 0.83 | MAP4K1 (0.44) | GSK3BDYRK1AWNT1MAP4K1TYRO3 | |
| SCHEMBL13574038 | 0.82 | TYRO3 (0.41) | GSK3BDYRK1AWNT1MAP4K1CDK2 | |
| SCHEMBL13336131 | 0.82 | TYRO3 (0.41) | GSK3BDYRK1AWNT1MAP4K1CDK2 | |
| SCHEMBL13336248 | 0.80 | SYK (0.44) | GSK3BDYRK1AWNT1CDK1TTK | |
| SCHEMBL13336218 | 0.80 | TYRO3 (0.39) | GSK3BDYRK1AWNT1MAP4K1CDK2 | |
| SCHEMBL13336028 | 0.80 | MAP4K1 (0.43) | GSK3BDYRK1AWNT1MAP4K1TYRO3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009153313-A1 | 2 -ARYLAMINOQUINAZOLINES FOR TREATING PROLIFERATIVE DISEASES | NOVARTIS AG (CH) | 2009-12-23 | — | — | WO | disclosed |