Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 3/20 | 0.44 |
| ▸ | MAP4K3 | Q8IVH8 | 1/20 | 0.44 |
| ▸ | BRAF | P15056 | 2/20 | 0.41 |
| ▸ | GSK3B | P49841 | 5/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 5/20 | 0.40 |
| ▸ | WNT1 | P04628 | 3/20 | 0.40 |
| ▸ | JUN | P05412 | 2/20 | 0.39 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.39 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.39 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.39 |
| ▸ | TYRO3 | Q06418 | 2/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.38 |
| ▸ | SYK | P43405 | 1/20 | 0.37 |
| ▸ | MET | P08581 | 1/20 | 0.37 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13573976 | 0.99 | MAP4K1 (0.44) | MAP4K1MAP4K3BRAFGSK3BDYRK1A | |
| SCHEMBL13362896 | 0.90 | MAP4K1 (0.43) | MAP4K1MAP4K3BRAFGSK3BDYRK1A | |
| SCHEMBL13336028 | 0.90 | MAP4K1 (0.43) | MAP4K1MAP4K3BRAFGSK3BDYRK1A | |
| SCHEMBL13574019 | 0.90 | GRM2 (0.42) | MAP4K1MAP4K3GSK3BDYRK1AWNT1 | |
| SCHEMBL13574033 | 0.90 | MAP4K1 (0.43) | MAP4K1MAP4K3GSK3BDYRK1AWNT1 | |
| SCHEMBL13336031 | 0.88 | MAP4K1 (0.42) | MAP4K1MAP4K3BRAFGSK3BDYRK1A | |
| SCHEMBL13336034 | 0.87 | MAP4K1 (0.42) | MAP4K1MAP4K3BRAFGSK3BDYRK1A | |
| SCHEMBL13363267 | 0.85 | BRAF (0.54) | MAP4K1MAP4K3BRAFACHESYK | |
| SCHEMBL13574009 | 0.85 | FGFR1 (0.41) | MAP4K1MAP4K3JUNMAPK8MAPK10 | |
| SCHEMBL13574022 | 0.84 | GSK3B (0.44) | MAP4K1MAP4K3GSK3BDYRK1AWNT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009153313-A1 | 2 -ARYLAMINOQUINAZOLINES FOR TREATING PROLIFERATIVE DISEASES | NOVARTIS AG (CH) | 2009-12-23 | — | — | WO | disclosed |