Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 13/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.41 |
| ▸ | MAP4K3 | Q8IVH8 | 1/20 | 0.40 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.40 |
| ▸ | WNT1 | P04628 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.38 |
| ▸ | TTK | P33981 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.37 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.37 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.37 |
| ▸ | CDK1 | P06493 | 1/20 | 0.37 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.37 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | CDK9 | P50750 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13574038 | 0.93 | TYRO3 (0.41) | AXLMAP4K3MAP4K1WNT1GSK3B | |
| SCHEMBL13362824 | 0.90 | AXL (0.42) | AXLFGFR1MAP4K3MAP4K1AURKB | |
| SCHEMBL13336230 | 0.90 | AXL (0.42) | AXLFGFR1MAP4K3MAP4K1AURKA | |
| SCHEMBL13336131 | 0.83 | TYRO3 (0.41) | AXLMAP4K3MAP4K1WNT1GSK3B | |
| SCHEMBL13574026 | 0.83 | GSK3B (0.43) | AXLMAP4K3MAP4K1WNT1GSK3B | |
| SCHEMBL13336218 | 0.81 | TYRO3 (0.39) | AXLFGFR1MAP4K3MAP4K1WNT1 | |
| SCHEMBL13336250 | 0.79 | SYK (0.42) | AXLFGFR1AURKAAURKBWNT1 | |
| SCHEMBL13362896 | 0.77 | MAP4K1 (0.43) | MAP4K3MAP4K1WNT1GSK3BDYRK1A | |
| SCHEMBL13335984 | 0.75 | MAP4K1 (0.45) | AXLFGFR1MAP4K3MAP4K1WNT1 | |
| SCHEMBL13574022 | 0.75 | GSK3B (0.44) | AXLMAP4K3MAP4K1WNT1GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009153313-A1 | 2 -ARYLAMINOQUINAZOLINES FOR TREATING PROLIFERATIVE DISEASES | NOVARTIS AG (CH) | 2009-12-23 | — | — | WO | disclosed |