Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OGA | O60502 | 5/20 | 0.61 |
| ▸ | CXCR4 | P61073 | 2/20 | 0.60 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.56 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.56 |
| ▸ | HRH4 | Q9H3N8 | 8/20 | 0.50 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.50 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.50 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.50 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.50 |
| ▸ | HTR1D | P28221 | 2/20 | 0.50 |
| ▸ | HTR2C | P28335 | 2/20 | 0.50 |
| ▸ | HTR2B | P41595 | 2/20 | 0.50 |
| ▸ | HRH2 | P25021 | 1/20 | 0.50 |
| ▸ | HTR2A | P28223 | 1/20 | 0.50 |
| ▸ | HTR7 | P34969 | 1/20 | 0.50 |
| ▸ | HTR5A | P47898 | 1/20 | 0.50 |
| ▸ | HTR6 | P50406 | 1/20 | 0.50 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.50 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1088599 | 0.99 | CXCR4 (0.63) | OGACXCR4ADORA2AADORA1HRH4 | |
| SCHEMBL1588315 | 0.88 | HRH4 (0.63) | OGACXCR4HRH4HRH3ADRA2B | |
| SCHEMBL1587997 | 0.88 | HRH4 (0.66) | OGACXCR4HRH4HRH3ADRA2B | |
| SCHEMBL26708280 | 0.83 | CXCR4 (0.63) | OGACXCR4HRH4HRH3ADRA2B | |
| SCHEMBL847331 | 0.81 | HRH4 (0.65) | OGAHRH4HRH3ADRA2BADRA2C | |
| SCHEMBL1589282 | 0.81 | HRH4 (0.65) | OGAHRH4HRH3ADRA2BADRA2C | |
| SCHEMBL19459031 | 0.81 | HRH4 (0.65) | OGAHRH4HRH3ADRA2BADRA2C | |
| SCHEMBL847664 | 0.81 | OGA (0.56) | OGAHRH4HRH3ADRA2BADRA2C | |
| SCHEMBL1822887 | 0.80 | HRH4 (0.67) | OGAHRH4HRH3ADRA2BADRA2C | |
| SCHEMBL860555 | 0.80 | OGA (0.60) | OGAHRH4HRH3ADRA2BADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009152325-A1 | DIAMINO-PYRIDINE, PYRIMIDINE, AND PYRIDAZINE MODULATORS OF THE HISTAMINE H4 RECEPTOR | JANSSEN PHARMACEUTICA NV (BE) | 2009-12-17 | — | — | WO | disclosed |