Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 13/20 | 0.65 |
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.65 |
| ▸ | OGA | O60502 | 6/20 | 0.59 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.48 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.48 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.48 |
| ▸ | HTR1D | P28221 | 2/20 | 0.48 |
| ▸ | HTR2C | P28335 | 2/20 | 0.48 |
| ▸ | HTR2B | P41595 | 2/20 | 0.48 |
| ▸ | HRH2 | P25021 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | HTR7 | P34969 | 1/20 | 0.44 |
| ▸ | HTR5A | P47898 | 1/20 | 0.44 |
| ▸ | HTR6 | P50406 | 1/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.44 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1589282 | 1.00 | HRH4 (0.65) | HRH4HRH3OGAADRA2BADRA2C | |
| SCHEMBL847331 | 1.00 | HRH4 (0.65) | HRH4HRH3OGAADRA2BADRA2C | |
| SCHEMBL1588714 | 0.87 | HRH4 (0.69) | HRH4HRH3OGAADRA2BADRA2C | |
| SCHEMBL860554 | 0.84 | OGA (0.60) | HRH4HRH3OGAADRA2BADRA2C | |
| SCHEMBL1589173 | 0.84 | HRH4 (0.67) | HRH4HRH3OGAADRA2BADRA2C | |
| SCHEMBL1822888 | 0.84 | HRH4 (0.67) | HRH4HRH3OGAADRA2BADRA2C | |
| SCHEMBL860555 | 0.84 | OGA (0.60) | HRH4HRH3OGAADRA2BADRA2C | |
| SCHEMBL1822887 | 0.84 | HRH4 (0.67) | HRH4HRH3OGAADRA2BADRA2C | |
| SCHEMBL846741 | 0.82 | OGA (0.73) | HRH4HRH3OGAADRA2BADRA2C | |
| SCHEMBL13574641 | 0.81 | OGA (0.61) | HRH4HRH3OGAADRA2BADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170298022-A1 | Diamino-Pyridine, Pyrimidine, and Pyridazine Modulators of the Histamine H4 Receptor | JANSSEN PHARMACEUTICA NV (BE) | 2017-10-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170298022-A1 | Diamino-Pyridine, Pyrimidine, and Pyridazine Modulators of the Histamine H4 Receptor | HRH4, HRH3, HRH1 | HRH4 1/4885HRH3 2/4885OGA 4864/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.