Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 2/20 | 0.38 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.34 |
| ▸ | CDK7 | P50613 | 1/20 | 0.34 |
| ▸ | CDK9 | P50750 | 1/20 | 0.34 |
| ▸ | CCNH | P51946 | 1/20 | 0.34 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.34 |
| ▸ | MAP3K14 | Q99558 | 3/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.33 |
| ▸ | PIKFYVE | Q9Y2I7 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.33 |
| ▸ | CDC7 | O00311 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.32 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.32 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.32 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.32 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.32 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1612885 | 0.91 | DYRK1A (0.48) | DYRK1ACCNT1CDK7CDK9CCNH | |
| SCHEMBL1612961 | 0.76 | DYRK1A (0.67) | DYRK1ACCNT1CDK7CDK9CCNH | |
| SCHEMBL1613333 | 0.76 | DYRK1A (0.51) | DYRK1ACCNT1CDK7CDK9CCNH | |
| SCHEMBL1614081 | 0.75 | PAK4 (0.45) | DYRK1ACCNT1CDK7CDK9CCNH | |
| SCHEMBL1614094 | 0.73 | PAK4 (0.43) | DYRK1ACCNT1CDK7CDK9CCNH | |
| SCHEMBL1614097 | 0.72 | PAK4 (0.44) | DYRK1ACCNT1CDK7CDK9CCNH | |
| SCHEMBL1614344 | 0.72 | CCNT1 (0.41) | DYRK1ACCNT1CDK7CDK9CCNH | |
| SCHEMBL12714670 | 0.72 | CCNT1 (0.41) | DYRK1ACCNT1CDK7CDK9CCNH | |
| SCHEMBL1826891 | 0.72 | CCNT1 (0.41) | DYRK1ACCNT1CDK7CDK9CCNH | |
| SCHEMBL1613487 | 0.71 | MAP3K14 (0.56) | MAP3K14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009158011-A1 | ALKYNYL ALCOHOLS AS KINASE INHIBITORS | AMGEN INC. (US) | 2009-12-30 | — | — | WO | disclosed |