Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNT1 | O60563 | 3/20 | 0.41 |
| ▸ | CDK7 | P50613 | 3/20 | 0.41 |
| ▸ | CDK9 | P50750 | 3/20 | 0.41 |
| ▸ | CCNH | P51946 | 3/20 | 0.41 |
| ▸ | MNAT1 | P51948 | 3/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.40 |
| ▸ | MAP3K14 | Q99558 | 8/20 | 0.36 |
| ▸ | PAK4 | O96013 | 3/20 | 0.36 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.36 |
| ▸ | PAK2 | Q13177 | 1/20 | 0.36 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.36 |
| ▸ | PAK6 | Q9NQU5 | 1/20 | 0.36 |
| ▸ | PAK5 | Q9P286 | 1/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.35 |
| ▸ | PIKFYVE | Q9Y2I7 | 1/20 | 0.34 |
| ▸ | CHUK | O15111 | 1/20 | 0.31 |
| ▸ | CCNK | O75909 | 1/20 | 0.31 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.31 |
| ▸ | CDK2 | P24941 | 1/20 | 0.31 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12714670 | 1.00 | CCNT1 (0.41) | CCNT1CDK7CDK9CCNHMNAT1 | |
| SCHEMBL1614344 | 1.00 | CCNT1 (0.41) | CCNT1CDK7CDK9CCNHMNAT1 | |
| SCHEMBL1614081 | 0.90 | PAK4 (0.45) | CCNT1CDK7CDK9CCNHMNAT1 | |
| SCHEMBL1614094 | 0.85 | PAK4 (0.43) | CCNT1CDK7CDK9CCNHMNAT1 | |
| SCHEMBL12742580 | 0.85 | CCNT1 (0.42) | CCNT1CDK7CDK9CCNHMNAT1 | |
| SCHEMBL1614097 | 0.85 | PAK4 (0.44) | CCNT1CDK7CDK9CCNHMNAT1 | |
| SCHEMBL12714662 | 0.81 | CHUK (0.41) | CCNT1CDK7CDK9CCNHMNAT1 | |
| SCHEMBL1614037 | 0.80 | MAP3K14 (0.47) | DYRK1AMAP3K14PAK4PAK1PAK2 | |
| SCHEMBL13575081 | 0.80 | NPC1 (0.38) | CCNT1CDK7CDK9CCNHMNAT1 | |
| SCHEMBL1612885 | 0.80 | DYRK1A (0.48) | CCNT1CDK7CDK9CCNHMNAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2315751-A1 | ALKYNYL ALCOHOLS AS KINASE INHIBITORS | Amgen Inc. (US) | 2011-05-04 | — | — | EP | disclosed |
| WO-2009158011-A1 | ALKYNYL ALCOHOLS AS KINASE INHIBITORS | AMGEN INC. (US) | 2009-12-30 | — | — | WO | disclosed |