Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 7/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.45 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.44 |
| ▸ | MAOA | P21397 | 3/20 | 0.44 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.42 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.42 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.42 |
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | MET | P08581 | 1/20 | 0.39 |
| ▸ | S100A4 | P26447 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13575489 | 0.86 | HTR4 (0.49) | KDM1AHPGD | |
| SCHEMBL2060204 | 0.84 | HPGD (0.55) | KDM1AHPGDNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL13575564 | 0.84 | HTR4 (0.52) | KDM1AHPGDNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL1781337 | 0.82 | ACKR3 (0.49) | HPGDNPC1RAB9ASMN1; SMN2USP30 | |
| SCHEMBL13161899 | 0.80 | HPGD (0.56) | KDM1AHPGDNPC1RAB9ACHEK1 | |
| SCHEMBL13161908 | 0.80 | HPGD (0.52) | KDM1AHPGDCHEK1PIK3C3CSNK2A2 | |
| SCHEMBL13575589 | 0.80 | HDAC6 (0.55) | KDM1ANPC1RAB9AUSP30KCNH2 | |
| SCHEMBL23133319 | 0.79 | NPC1 (0.47) | KDM1AHPGDNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL3546444 | 0.79 | HTR4 (0.57) | HPGDKCNH2 | |
| SCHEMBL31171310 | 0.78 | USP30 (0.49) | KDM1AHPGDNPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009153197-A1 | HALO-SUBSTITUTED PYRIMIDODIAZEPINES AS PLKL INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-12-23 | — | — | WO | disclosed |