Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 3/20 | 0.46 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.46 |
| ▸ | CNR2 | P34972 | 3/20 | 0.43 |
| ▸ | CNR1 | P21554 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | PDE4A | P27815 | 3/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.40 |
| ▸ | PRPS1 | P60891 | 2/20 | 0.39 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4827022 | 0.89 | SCN9A (0.46) | SCN9ASCN5ACNR2CNR1ALDH1A1 | |
| SCHEMBL4830054 | 0.87 | SCN9A (0.49) | SCN9ASCN5ACNR2CNR1ALDH1A1 | |
| SCHEMBL13577940 | 0.85 | HPGD (0.44) | SCN9ASCN5ACNR2CNR1ALDH1A1 | |
| SCHEMBL14435340 | 0.84 | SCN9A (0.45) | SCN9ASCN5ACNR2CNR1ALDH1A1 | |
| SCHEMBL772052 | 0.82 | HRH2 (0.44) | SCN9ASCN5ACNR2CNR1ALDH1A1 | |
| SCHEMBL13577944 | 0.82 | LMNA (0.45) | SCN9ASCN5ACNR2CNR1ALDH1A1 | |
| SCHEMBL1260945 | 0.81 | SCN9A (0.65) | SCN9ASCN5ACNR2CNR1ALDH1A1 | |
| SCHEMBL899454 | 0.80 | SCN9A (0.64) | SCN9ASCN5ACNR2CNR1ALDH1A1 | |
| SCHEMBL4831650 | 0.80 | HRH2 (0.48) | SCN9ASCN5ACNR2HRH2 | |
| SCHEMBL4324275 | 0.79 | TLR8 (0.43) | CNR2CNR1ALDH1A1KDM4ECYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009147121-A1 | CARBOXYL SUBSTITUTED INDOLES FOR USE AS PPAR ALPHA MODULATORS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-12-10 | — | — | WO | disclosed |