Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX3 | P56373 | 2/20 | 0.47 |
| ▸ | P2RX2 | Q9UBL9 | 2/20 | 0.47 |
| ▸ | PTGDR2 | Q9Y5Y4 | 8/20 | 0.40 |
| ▸ | GFRA3 | O60609 | 2/20 | 0.36 |
| ▸ | RET | P07949 | 1/20 | 0.36 |
| ▸ | GFRA2 | O00451 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | PDE4A | P27815 | 1/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1944156 | 0.89 | PTGDR2 (0.48) | P2RX3P2RX2PTGDR2 | |
| SCHEMBL1010011 | 0.89 | PTGDR2 (0.48) | P2RX3P2RX2PTGDR2 | |
| SCHEMBL1942947 | 0.89 | PTGDR2 (0.48) | P2RX3P2RX2PTGDR2 | |
| SCHEMBL137268 | 0.84 | PTGDR2 (0.49) | PTGDR2 | |
| SCHEMBL137402 | 0.84 | PTGDR2 (0.49) | PTGDR2 | |
| SCHEMBL1009037 | 0.81 | P2RX3 (0.41) | P2RX3P2RX2PTGDR2CYP2D6 | |
| SCHEMBL1008659 | 0.81 | PTGDR2 (0.50) | P2RX3P2RX2PTGDR2 | |
| SCHEMBL1944800 | 0.81 | P2RX3 (0.41) | P2RX3P2RX2PTGDR2CYP2D6 | |
| SCHEMBL1943229 | 0.81 | PTGDR2 (0.50) | P2RX3P2RX2PTGDR2 | |
| SCHEMBL1942276 | 0.81 | PTGDR2 (0.50) | P2RX3P2RX2PTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009145989-A2 | AMINOALKYLPHENYL ANTAGONISTS OF PROSTAGLANDIN D2 RECEPTORS | AMIRA PHARMACEUTICALS, INC. (US) | 2009-12-03 | — | — | WO | disclosed |