Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 20/20 | 1.00 |
| ▸ | DRD3 | P35462 | 20/20 | 1.00 |
| ▸ | DRD2 | P14416 | 19/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13583786 | 1.00 | HTR2A (1.00) | HTR2ADRD3DRD2 | |
| SCHEMBL13584432 | 0.94 | HTR2A (1.00) | HTR2ADRD3DRD2 | |
| SCHEMBL13584431 | 0.94 | HTR2A (1.00) | HTR2ADRD3DRD2 | |
| SCHEMBL13584272 | 0.93 | HTR2A (1.00) | HTR2ADRD3DRD2 | |
| SCHEMBL13584397 | 0.93 | HTR2A (1.00) | HTR2ADRD3DRD2 | |
| SCHEMBL13584273 | 0.93 | HTR2A (1.00) | HTR2ADRD3DRD2 | |
| SCHEMBL13583354 | 0.93 | HTR2A (1.00) | HTR2ADRD3DRD2 | |
| SCHEMBL13584398 | 0.93 | HTR2A (1.00) | HTR2ADRD3DRD2 | |
| SCHEMBL13583350 | 0.93 | HTR2A (1.00) | HTR2ADRD3DRD2 | |
| SCHEMBL13644192 | 0.93 | HTR2A (0.86) | HTR2ADRD3DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2704707-A1 | NOVEL BENZOFURANE-PIPERIDINE COMPOUNDS | F. Hoffmann-La Roche AG (CH) | 2014-03-12 | — | — | EP | claimed |
| US-20120283254-A1 | NOVEL BENZOFURANE-PIPERIDINE COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2012-11-08 | — | — | US | claimed |
| WO-2012150231-A1 | NOVEL BENZOFURANE-PIPERIDINE COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2012-11-08 | — | — | WO | claimed |
| US-8921397-B2 | Benzofurane-piperidine compounds | HOFFMANN-LA ROCHE INC. (US) | 2014-12-30 | — | — | US | disclosed |
| US-8921397-B2 | Benzofurane-piperidine compounds | HOFFMANN-LA ROCHE INC. (US) | 2014-12-30 | — | — | US | disclosed |
| US-8921397-B2 | Benzofurane-piperidine compounds | HOFFMANN-LA ROCHE INC. (US) | 2014-12-30 | — | — | US | disclosed |
| EP-2704707-A1 | NOVEL BENZOFURANE-PIPERIDINE COMPOUNDS | F. Hoffmann-La Roche AG (CH) | 2014-03-12 | — | — | EP | disclosed |
| WO-2012150231-A1 | NOVEL BENZOFURANE-PIPERIDINE COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2012-11-08 | — | — | WO | disclosed |
| US-20120283254-A1 | NOVEL BENZOFURANE-PIPERIDINE COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2012-11-08 | — | — | US | disclosed |
| US-20120283254-A1 | NOVEL BENZOFURANE-PIPERIDINE COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2012-11-08 | — | — | US | disclosed |
| US-20120283254-A1 | NOVEL BENZOFURANE-PIPERIDINE COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2012-11-08 | — | — | US | disclosed |
| WO-2012150231-A1 | NOVEL BENZOFURANE-PIPERIDINE COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2012-11-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120283254-A1 | NOVEL BENZOFURANE-PIPERIDINE COMPOUNDS | HTR2A, HTR2C, HTR1E | HTR2A 1/4885DRD3 32/4885DRD2 21/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.