HTR1E — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL111992	0.58	6/20
SCHEMBL607926	0.41	6/20
SCHEMBL183540	0.74	4/20
SCHEMBL183687	0.74	4/20
SCHEMBL178071	0.64	4/20
SCHEMBL257961	0.64	4/20
SCHEMBL517481	0.61	4/20
SCHEMBL609492	0.40	4/20
SCHEMBL194700	0.82	3/20
SCHEMBL517473	0.65	3/20
Bufotenine (SCHEMBL518028)	0.65	3/20
SCHEMBL69127	0.65	3/20
SCHEMBL67219	0.63	3/20
SCHEMBL193456	0.63	3/20
SCHEMBL194699	0.62	3/20
SCHEMBL67619	0.60	3/20
SCHEMBL325572	0.59	3/20
SCHEMBL326780	0.56	3/20
SCHEMBL66920	0.54	3/20
SCHEMBL235595	0.50	3/20

Clinical trials — most relevant to HTR1E by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
The Relationship Among Changes in Brain Network Activation in Adult Outpatients With Major Depressive Disorder	PHASE4	COMPLETED
Serotonin Transporter Genetic Variation and Amygdala Responses to Antidepressant Medications in Major Depression	PHASE4	COMPLETED
Medication, Weight Gain and GI Hormones	PHASE4	COMPLETED
Serotonin-receptor Agonism in Reward Processing	PHASE2	COMPLETED
Psilocybe Cubensis Mushrooms With or Without Fluoxetine for Refractory Depression	PHASE1/PHASE2	RECRUITING
The Effect of Ginger on the Incidence of Postoperative Nausea and Vomiting	PHASE2	COMPLETED
5HT2CR Balance in Brain Connectivity in Cocaine Dependence	PHASE1/PHASE2	COMPLETED
The Neurobiological Effect of 5-HT2AR Modulation	PHASE1	RECRUITING
Evaluation of [18F]MPPF as a Brain Tracer of Serotonin Receptor 5HT1a	PHASE1	COMPLETED
Brain Imaging, Genetics and Treatment for Major Depression	PHASE1	WITHDRAWN
A Dose-Ranging Study of JNJ-40411813 in Healthy Male Volunteers	PHASE1	COMPLETED
Effects of SERT Inhibition on the Subjective Response to Psilocybin in Healthy Subjects	PHASE1	COMPLETED
SRC Inhibition as a Potential Target for Parkinson's Disease Psychosis	EARLY_PHASE1	UNKNOWN
Trazodone and the Risk of Serious Adverse Events	nan	COMPLETED
PET Whole Body Distribution Studies Using [11C]CUMI	nan	COMPLETED
The Pill Project - Oral Contraceptive and Serotonergic Brain Signaling	nan	UNKNOWN
Evaluation of [11C]Cimbi-36 as an Agonist PET Radioligand for Imaging of 5-HT2A Receptors	nan	COMPLETED
Epigenetic and Neurochemical Correlates of Bipolar Disorder	nan	NOT_YET_RECRUITING
Hormonal Causes of Menstrual-Related Mood Disorders	nan	COMPLETED
Genetic Variants Associated With Adolescent Suicide Attempts	nan	COMPLETED
Endophenotype, Molecular Genetic Study on Attention-Deficit/Hyperactivity Disorder	nan	COMPLETED
Investigating Serotonin Signalling in IBD Patients	nan	RECRUITING
The Role of 5-HT2A Receptor in the Perception of Self and Personal Meaning in Healthy Volunteers	nan	COMPLETED
Examination of Brain Serotonin Receptors in Patients With Mood Disorders	nan	COMPLETED
Using Fenfluramine to Test the Serotonin Deficiency Theory of Depression	nan	NOT_YET_RECRUITING
The Efficacy of Tianeptine Versus Pregabalin on Acute and Chronic Post Mastectomy Pain After Breast Cancer Surgery.	nan	COMPLETED
Investigating the Neuropsychological Effects of 5-HT2a Antagonism	nan	RECRUITING
The Role of Sex Steroids and Serotonin Brain Dynamics in Perinatal Mental Health	nan	COMPLETED
Effects of Lurasidone on Left Ventricle Systolic Functions	nan	NOT_YET_RECRUITING
5-HT7 Receptor Implication in Inflammatory Mechanisms in Multiple Sclerosis	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a HTR1E binder may also engage these)

Protein	Name	Similarity
Q9N2B6	—	1.000	Q9N2B6 →
Q6VB83	—	1.000	Q6VB83 →
P30940	—	1.000	P30940 →
Q9N2D9	—	1.000	Q9N2D9 →
O42384	—	0.998	O42384 →
P79748	—	0.997	P79748 →
O08890	—	0.996	O08890 →
HTR4	5-hydroxytryptamine receptor 4	0.995	landscape →
P28564	—	0.995	P28564 →
Q02284	—	0.994	Q02284 →
HTR1F	5-hydroxytryptamine receptor 1F	0.994	landscape →
P35404	—	0.994	P35404 →
P97288	—	0.994	P97288 →
O70528	—	0.993	O70528 →
HTR1B	5-hydroxytryptamine receptor 1B	0.993	landscape →
P18901	—	0.993	P18901 →
Q588Y6	—	0.993	Q588Y6 →
Q91081	—	0.993	Q91081 →
P56496	—	0.993	P56496 →
HTR1D	5-hydroxytryptamine receptor 1D	0.992	landscape →
P50130	—	0.992	P50130 →
O42385	—	0.991	O42385 →
Q9N2B7	—	0.991	Q9N2B7 →
DRD1	D(1A) dopamine receptor	0.991	landscape →
P49144	—	0.991	P49144 →
P46636	—	0.991	P46636 →
Q0EAB5	—	0.990	Q0EAB5 →
P79250	—	0.990	P79250 →
Q6XXX8	—	0.990	Q6XXX8 →
P79400	—	0.990	P79400 →