Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 3/20 | 0.64 |
| ▸ | KDR | P35968 | 4/20 | 0.55 |
| ▸ | AXL | P30530 | 3/20 | 0.49 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.49 |
| ▸ | AURKA | O14965 | 2/20 | 0.49 |
| ▸ | LCK | P06239 | 2/20 | 0.49 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.49 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.49 |
| ▸ | PLK4 | O00444 | 1/20 | 0.49 |
| ▸ | GAK | O14976 | 1/20 | 0.49 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.49 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.49 |
| ▸ | STK10 | O94804 | 1/20 | 0.49 |
| ▸ | ABL1 | P00519 | 1/20 | 0.49 |
| ▸ | EGFR | P00533 | 1/20 | 0.49 |
| ▸ | FYN | P06241 | 1/20 | 0.49 |
| ▸ | CSF1R | P07333 | 1/20 | 0.49 |
| ▸ | YES1 | P07947 | 1/20 | 0.49 |
| ▸ | LYN | P07948 | 1/20 | 0.49 |
| ▸ | RET | P07949 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13587168 | 0.89 | MET (0.65) | METKDRAXLPDGFRAAURKA | |
| SCHEMBL13587147 | 0.89 | MET (0.64) | METKDRAXLPDGFRAAURKA | |
| SCHEMBL13587151 | 0.89 | MET (0.64) | METKDRAXLPDGFRAAURKA | |
| SCHEMBL2747201 | 0.85 | MET (0.61) | METKDRAXLPDGFRAAURKA | |
| SCHEMBL4379209 | 0.85 | MET (0.70) | METKDRAXLPDGFRANPC1 | |
| SCHEMBL13587165 | 0.84 | MET (0.67) | METKDRAXLPDGFRAAURKA | |
| SCHEMBL13587174 | 0.83 | AXL (0.71) | METKDRAXLPDGFRAAURKA | |
| SCHEMBL4368604 | 0.82 | MET (0.77) | METKDRPDGFRAKITNPC1 | |
| SCHEMBL4379973 | 0.82 | MET (0.71) | METKDRAURKALCKAURKB | |
| SCHEMBL2748777 | 0.82 | KDR (0.69) | METKDRAURKALCKAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7626030-B2 | Compounds and methods of use | AMGEN INC. (US) | 2009-12-01 | — | — | US | disclosed |
| US-7626030-B2 | Compounds and methods of use | AMGEN INC. (US) | 2009-12-01 | — | — | US | disclosed |