Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 5/20 | 0.67 |
| ▸ | KDR | P35968 | 13/20 | 0.54 |
| ▸ | NPC1 | O15118 | 5/20 | 0.54 |
| ▸ | RAB9A | P51151 | 5/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | TP53 | P04637 | 3/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | HPGD | P15428 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | CASP1 | P29466 | 1/20 | 0.54 |
| ▸ | CASP7 | P55210 | 1/20 | 0.54 |
| ▸ | AXL | P30530 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | AURKA | O14965 | 4/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13587167 | 0.90 | MET (0.66) | METKDRNPC1RAB9AALDH1A1 | |
| SCHEMBL13587154 | 0.90 | NPC1 (0.68) | METKDRNPC1RAB9AALDH1A1 | |
| SCHEMBL13587159 | 0.89 | MET (0.64) | METKDRNPC1RAB9AALDH1A1 | |
| SCHEMBL13587152 | 0.88 | MET (0.63) | METKDRNPC1RAB9AALDH1A1 | |
| SCHEMBL13587174 | 0.87 | AXL (0.71) | METKDRNPC1RAB9AALDH1A1 | |
| SCHEMBL4378894 | 0.87 | MET (0.68) | METKDRNPC1RAB9AALDH1A1 | |
| SCHEMBL4379209 | 0.86 | MET (0.70) | METKDRNPC1RAB9AALDH1A1 | |
| SCHEMBL13587165 | 0.86 | MET (0.67) | METKDRNPC1RAB9AALDH1A1 | |
| SCHEMBL4368604 | 0.86 | MET (0.77) | METKDRNPC1RAB9ATP53 | |
| SCHEMBL4367742 | 0.85 | MET (0.71) | METKDRNPC1RAB9AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7626030-B2 | Compounds and methods of use | AMGEN INC. (US) | 2009-12-01 | — | — | US | disclosed |
| US-7626030-B2 | Compounds and methods of use | AMGEN INC. (US) | 2009-12-01 | — | — | US | disclosed |