Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 9/20 | 0.77 |
| ▸ | CYP1A2 | P05177 | 8/20 | 0.77 |
| ▸ | CYP2C8 | P10632 | 6/20 | 0.77 |
| ▸ | CYP2C19 | P33261 | 6/20 | 0.77 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.77 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.77 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.76 |
| ▸ | APP | P05067 | 4/20 | 0.66 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.66 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.66 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.66 |
| ▸ | HTR1A | P08908 | 1/20 | 0.66 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.66 |
| ▸ | DRD2 | P14416 | 1/20 | 0.66 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.66 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.66 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.66 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.66 |
| ▸ | HTR2B | P41595 | 1/20 | 0.66 |
| ▸ | CYP2J2 | P51589 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20536597 | 0.93 | CYP2D6 (0.77) | CYP2D6CYP1A2CYP2C8CYP2C19KCNH2 | |
| Isoquine SCHEMBL5836418 | 0.87 | CYP2D6 (1.00) | CYP2D6CYP1A2CYP2C8CYP2C19KCNH2 | |
| SCHEMBL23343459 | 0.87 | CYP2D6 (0.68) | CYP2D6CYP1A2CYP2C8CYP2C19KCNH2 | |
| Isoquine SCHEMBL31672531 | 0.86 | CYP3A4 (1.00) | CYP2D6CYP1A2CYP2C8CYP2C19KCNH2 | |
| SCHEMBL20536650 | 0.86 | CYP2D6 (0.67) | CYP2D6CYP1A2CYP2C8CYP2C19KCNH2 | |
| SCHEMBL23343458 | 0.85 | CYP2D6 (0.66) | CYP2D6CYP1A2CYP2C8CYP2C19KCNH2 | |
| SCHEMBL20536486 | 0.83 | CYP2D6 (0.63) | CYP2D6CYP1A2CYP2C8CYP2C19KCNH2 | |
| SCHEMBL20536652 | 0.82 | CYP2D6 (0.77) | CYP2D6CYP1A2CYP2C8CYP2C19KCNH2 | |
| SCHEMBL20536430 | 0.81 | CYP2D6 (0.61) | CYP2D6CYP1A2CYP2C8CYP2C19KCNH2 | |
| SCHEMBL15894079 | 0.81 | CYP2D6 (0.78) | CYP2D6CYP1A2CYP2C8CYP2C19KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090298868-A1 | QUINOLINE COMPOUNDS AS MELANOGENESIS MODIFIERS AND USES THEREOF | ORLOW SETH J | 2009-12-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090298868-A1 | QUINOLINE COMPOUNDS AS MELANOGENESIS MODIFIERS AND USES THEREOF | TYR, MITF, MC1R | CYP2D6 473/4885CYP1A2 172/4885CYP2C8 1197/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.