MITF

Microphthalmia-associated transcription factor · O75030 · MITF on Sugi Atlas →

118,751 patent compounds predicted against MITF, 84,319 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL99040	0.49	7/20
Nitrofurazone (SCHEMBL25416)	0.66	4/20
Nitrofurazone (SCHEMBL25417)	0.66	4/20
SCHEMBL44662	0.78	3/20
Dichlon (SCHEMBL45723)	0.58	3/20
Nifuratel (SCHEMBL153098)	0.56	3/20
Nifuratel (SCHEMBL153100)	0.56	3/20
SCHEMBL134428	0.54	3/20
Furaltadone (SCHEMBL49267)	0.52	3/20
Furaltadone (SCHEMBL49268)	0.52	3/20
Furaltadone (SCHEMBL49269)	0.52	3/20
Nifurtimox (SCHEMBL60839)	0.51	3/20
Nifurtimox (SCHEMBL60840)	0.51	3/20
Eprazinone (SCHEMBL20156)	0.50	3/20
SCHEMBL81437	0.50	3/20
SCHEMBL106825	0.42	3/20
SCHEMBL106826	0.42	3/20
SCHEMBL79836	0.40	3/20
Homidium (SCHEMBL20520)	1.00	2/20
Homidium (SCHEMBL27609)	1.00	2/20

Clinical trials — most relevant to MITF by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
A Study of Sorafenib in Patients With Chemonaive Metastatic Uveal Melanoma	PHASE2	UNKNOWN
Comparative Efficacy of Resveratrol 1 % Gel and Trichloroacetic Acid 20% in Treatment of Melasma: A Split-face Study	nan	NOT_YET_RECRUITING
Molecular Analysis of Microphthalmia/Anophthalmia	nan	COMPLETED
The Role of Melanocyte in Basal Cell Carcinoma	nan	UNKNOWN
Secretome TGF Beta 3	nan	NOT_YET_RECRUITING
Histochemical Study of Vitiligo in Sohag University Hospital Patients	nan	UNKNOWN
miRNA Machinery in Melanoma, Melanoma Metastases and Benign Melanocytic Naevi	nan	COMPLETED
Clinical, Cellular, and Molecular Investigation Into Oculocutaneous Albinism	nan	COMPLETED
Role of SLURP-1 in Melanoma and Melanoma Stem Cells	nan	UNKNOWN
Fundus Changes in the Microphthalmy Eyes	nan	COMPLETED
Molecular Epidemiology of Cutaneous Malignant Melanoma	nan	COMPLETED
Autophagy in Systemic Lupus Erythematosus	nan	UNKNOWN
Natural History Study of Moles and Suspicious Melanoma	nan	COMPLETED
Characterization of Patients With Tuberous Sclerosis Complex, Lymphangioleiomyomatosis and Angiomyolipoma	nan	COMPLETED
Differences in Bone Cell Activity Between Rheumatoid Arthritis and Ankylosing Spondylitis	nan	COMPLETED
Pathogenesis and Genetics of Microphthalmia, Anophthalmia and Uveal Coloboma (MAC)	nan	RECRUITING
New Biopsy Technique for Uveal Melanoma	nan	COMPLETED
The Role of Genetic Mutations and of Circulating mRNAs in Uveal Melanoma	nan	UNKNOWN
Genetic Analysis of Familial Melanoma	nan	COMPLETED
Whole Transcriptome Profiling and Metabolic Phenotyping in Children With ROHHAD Syndrome	nan	RECRUITING
An In Vivo Model for Postinflammatory Hyperpigmentation	nan	COMPLETED
A Study on How to Safely Guide Surgery for Melanoma and Similar Skin Tumors in Children Using Pathology and Genetic Information	nan	NOT_YET_RECRUITING
Validation of a Molecular Prognostic Test for Eye Melanoma	nan	WITHDRAWN
Family Study of Melanoma in Italy	nan	COMPLETED
Identifying Gene Mutations in Patients With Melanoma and in Families With a History of Hereditary Melanoma	nan	UNKNOWN
Evaluation of Human Melanocytes After the Use of PRP Versus Fractional CO2 Laser in Vitiligo	nan	UNKNOWN
The Effects of Lutein and Zeaxanthin Supplementation on Vision in Patients With Albinism	nan	COMPLETED
Diagnosis of RSTS: Identification of the Acetylation Profiles as Epigenetic Markers for Assessing Causality of CREBBP and EP300 Variants.	nan	UNKNOWN
NGS Panel of Incomplete Forms of Ocular Albinism	nan	COMPLETED
Investigating the Genetic Basis of Pseudoexfoliation Syndrome, Angle-closure Glaucoma and Primary Open-angle Glaucoma	nan	RECRUITING

Related proteins — ESM-2 sequence neighbours (a MITF binder may also engage these)

Protein	Name	Similarity
Q08874	—	1.000	Q08874 →
Q60430	—	1.000	Q60430 →
Q5RER5	—	1.000	Q5RER5 →
Q26263	—	0.999	Q26263 →
P22361	—	0.999	P22361 →
P20912	—	0.999	P20912 →
O94900	—	0.999	O94900 →
P40426	—	0.999	P40426 →
O88368	—	0.998	O88368 →
TFDP2	Transcription factor Dp-2	0.998	landscape →
Q9YGY4	—	0.998	Q9YGY4 →
Q9UPW0	—	0.997	Q9UPW0 →
Q8STF6	—	0.997	Q8STF6 →
P58462	—	0.997	P58462 →
Q0VGT2	—	0.997	Q0VGT2 →
A0A8I3PQN6	—	0.997	A0A8I3PQN6 →
P41935	—	0.997	P41935 →
Q1KKW8	—	0.997	Q1KKW8 →
O01409	—	0.997	O01409 →
P42583	—	0.996	P42583 →
Q32NP8	—	0.996	Q32NP8 →
Q7ZY13	—	0.996	Q7ZY13 →
Q751A7	—	0.996	Q751A7 →
Q645N4	—	0.996	Q645N4 →
Q91904	—	0.996	Q91904 →
Q9QXN1	—	0.995	Q9QXN1 →
PAX8	Paired box protein Pax-8	0.995	landscape →
Q6DIF3	—	0.995	Q6DIF3 →
P84961	—	0.995	P84961 →
P40657	—	0.995	P40657 →