Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACKR3 | P25106 | 1/20 | 0.51 |
| ▸ | TBK1 | Q9UHD2 | 9/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.47 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14469361 | 0.91 | TBK1 (0.47) | ACKR3TBK1SMN1; SMN2ALDH1A1ROCK2 | |
| SCHEMBL13003343 | 0.87 | CYP3A4 (0.53) | TBK1 | |
| SCHEMBL8418718 | 0.87 | ACKR3 (0.55) | ACKR3TBK1 | |
| SCHEMBL14469500 | 0.85 | TBK1 (0.50) | ACKR3TBK1 | |
| SCHEMBL13588425 | 0.83 | TBK1 (0.51) | TBK1 | |
| SCHEMBL8420482 | 0.82 | ACKR3 (0.50) | ACKR3TBK1ADRB2 | |
| SCHEMBL14624187 | 0.82 | ACKR3 (0.48) | ACKR3TBK1SMN1; SMN2ALDH1A1HTT | |
| SCHEMBL13003648 | 0.80 | CYP3A4 (0.53) | TBK1 | |
| SCHEMBL13588426 | 0.79 | TBK1 (0.48) | TBK1 | |
| SCHEMBL8223229 | 0.79 | TBK1 (0.51) | TBK1SMN1; SMN2MEN1ALOX15TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1902046-B1 | PIPERIDINE DERIVATIVES USEFUL AS HISTAMINE H3 ANTAGONISTS | SCHERING CORP (US) | 2009-12-02 | — | — | EP | disclosed |