Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 10/20 | 0.51 |
| ▸ | JAK3 | P52333 | 5/20 | 0.51 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.50 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.50 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.50 |
| ▸ | CDK1 | P06493 | 1/20 | 0.49 |
| ▸ | CDK2 | P24941 | 1/20 | 0.49 |
| ▸ | IKBKB | O14920 | 4/20 | 0.48 |
| ▸ | CHUK | O15111 | 3/20 | 0.48 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.48 |
| ▸ | AIMP2 | Q13155 | 1/20 | 0.47 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.47 |
| ▸ | IKBKG | Q9Y6K9 | 1/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
| ▸ | NCOR1 | O75376 | 1/20 | 0.46 |
| ▸ | JAK1 | P23458 | 1/20 | 0.46 |
| ▸ | TYK2 | P29597 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4392408 | 0.91 | PIK3CA (0.51) | JAK2JAK3PIK3CAPIK3CBPIK3CG | |
| SCHEMBL14021327 | 0.91 | JAK2 (0.49) | JAK2JAK3PIK3CAPIK3CBPIK3CG | |
| SCHEMBL14063782 | 0.91 | JAK2 (0.52) | JAK2JAK3PIK3CAPIK3CBPIK3CG | |
| SCHEMBL8311018 | 0.90 | JAK2 (0.61) | JAK2JAK3PIK3CAPIK3CBPIK3CG | |
| SCHEMBL14063777 | 0.90 | JAK2 (0.49) | JAK2JAK3PIK3CAPIK3CBPIK3CG | |
| SCHEMBL14021629 | 0.90 | JAK2 (0.54) | JAK2JAK3PIK3CAPIK3CBPIK3CG | |
| SCHEMBL1512786 | 0.89 | PIK3CA (0.55) | JAK2JAK3PIK3CAPIK3CBPIK3CG | |
| SCHEMBL4063691 | 0.89 | JAK2 (0.52) | JAK2JAK3PIK3CAPIK3CBPIK3CG | |
| SCHEMBL14063781 | 0.89 | SYK (0.53) | JAK2JAK3PIK3CAPIK3CBPIK3CG | |
| SCHEMBL14021233 | 0.88 | CDK1 (0.49) | JAK2JAK3PIK3CAPIK3CBPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1349841-B1 | ANILINOPYRIMIDINE DERIVATIVES AS IKK INHIBITORS AND COMPOSITIONS AND METHODS RELATED THERETO | SIGNAL PHARM LLC (US) | 2009-12-02 | — | — | EP | disclosed |